KIFC1
| Kinesin family member C1 | |||||||||||||
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| Symbols | KIFC1 ; HSET; KNSL2 | ||||||||||||
| External IDs | OMIM: 603763 MGI: 109596 HomoloGene: 83229 GeneCards: KIFC1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3833 | 16580 | |||||||||||
| Ensembl | ENSG00000056678 | ENSMUSG00000024301 | |||||||||||
| UniProt | Q9BW19 | Q9QWT9 | |||||||||||
| RefSeq (mRNA) | NM_002263 | NM_016761 | |||||||||||
| RefSeq (protein) | NP_002254 | NP_444403 | |||||||||||
| Location (UCSC) | Chr 6: 33.36 – 33.38 Mb | Chr 17: 26.92 – 26.93 Mb | |||||||||||
| PubMed search | |||||||||||||
Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.[1][2]
Function
The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.
References
- ↑ Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T et al. (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics 39 (3): 194–200. doi:10.1007/bf00241260. PMID 8276466.
- ↑ "Entrez Gene: KIFC1 kinesin family member C1".
Further reading
- Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
- Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A et al. (1999). "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)". Immunogenetics 49 (7–8): 644–52. doi:10.1007/s002510050660. PMID 10369922.
- Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU et al. (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis". J. Cell Biol. 162 (5): 863–75. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
- Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Al-Bassam J, Roger B, Halpain S, Milligan RA (2007). "Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c". Cell Motil. Cytoskeleton 64 (5): 377–89. doi:10.1002/cm.20190. PMID 17326138.