KIF6
| Kinesin family member 6 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | KIF6 ; C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1 | ||||||||||||
| External IDs | OMIM: 613919 HomoloGene: 35308 GeneCards: KIF6 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 221458 | 319991 | |||||||||||
| Ensembl | ENSG00000164627 | ENSMUSG00000023999 | |||||||||||
| UniProt | Q6ZMV9 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001289020 | NM_177052 | |||||||||||
| RefSeq (protein) | NP_001275949 | NP_796026 | |||||||||||
| Location (UCSC) | Chr 6: 39.3 – 39.69 Mb | Chr 17: 49.62 – 49.91 Mb | |||||||||||
| PubMed search | |||||||||||||
Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene.[1] This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport.
References
Further Reading
- Koroleva, O. S.; Pushkov, A. A.; Blagodatskikh, K. A.; Baranova, O. A.; Azizova, O. A.; Nosikov, V. V.; Reznichenko, N. E.; Zateĭshchikov, D. A. (2011). "Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease". Kardiologiia 51 (9): 4–12. PMID 21943003.
- Bare, L. A.; Ruiz-Narvaéz, E. A.; Tong, C. H.; Arellano, A. R.; Rowland, C. M.; Catanese, J. J.; Sacks, F. M.; Devlin, J. J.; Campos, H (2010). "Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: A Costa Rican population". PLoS ONE 5 (9): e13081. doi:10.1371/journal.pone.0013081. PMC 2947524. PMID 20927332.
- Peng, P; Lian, J; Huang, R. S.; Xu, L; Huang, Y; Ba, Y; Yang, X; Huang, X; Dong, C; Zhang, L; Ye, M; Zhou, J; Duan, S (2012). "Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect". PLoS ONE 7 (12): e50126. doi:10.1371/journal.pone.0050126. PMC 3517591. PMID 23236363.
- Akao, H; Polisecki, E; Kajinami, K; Trompet, S; Robertson, M; Ford, I; Jukema, J. W.; De Craen, A. J.; Westendorp, R. G.; Shepherd, J; Packard, C; Buckley, B. M.; Schaefer, E. J. (2012). "KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly". Atherosclerosis 220 (2): 456–62. doi:10.1016/j.atherosclerosis.2011.11.037. PMID 22192511.
- Liu, X; Gomez-Pinillos, A; Loder, C; Carrillo-De Santa Pau, E; Qiao, R; Unger, P. D.; Kurek, R; Oddoux, C; Melamed, J; Gallagher, R. E.; Mandeli, J; Ferrari, A. C. (2012). "KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation". The American Journal of Pathology 181 (3): 1007–16. doi:10.1016/j.ajpath.2012.06.008. PMC 3432435. PMID 22819534.
- Davani, S; Gozalo, C; Gambert, S; Chalmers, D; Gambert, P; Schiele, F; Kantelip, J. P.; Meneveau, N (2010). "The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction". Atherosclerosis 210 (1): 48–50. doi:10.1016/j.atherosclerosis.2009.11.041. PMID 20044086.
- Hu, M; Lui, S. S.; Mak, V. W.; Chu, T. T.; Lee, V. W.; Poon, E. W.; Tsui, T. K.; Ko, G. T.; Baum, L; Tam, L. S.; Li, E. K.; Tomlinson, B (2010). "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients". Pharmacogenetics and Genomics 20 (10): 634–7. doi:10.1097/FPC.0b013e32833de489. PMID 20679960.
- Koroleva, O. S.; Zateĭshchikov, D. A. (2010). "Motor protein Kinesin-6 and ischemic heart disease". Kardiologiia 50 (6): 54–62. PMID 20659029.
- Bhanushali, A. A.; Contractor, A; Shah, V. T.; Das, B. R. (2011). "Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians". Genetic Testing and Molecular Biomarkers 15 (12): 883–6. doi:10.1089/gtmb.2011.0079. PMID 21810021.