KIF4A
| Kinesin family member 4A | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KIF4A ; KIF4; KIF4G1 | ||||||||||||
| External IDs | OMIM: 300521 MGI: 108389 HomoloGene: 69022 ChEMBL: 6163 GeneCards: KIF4A Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 24137 | 16571 | |||||||||||
| Ensembl | ENSG00000090889 | ENSMUSG00000034311 | |||||||||||
| UniProt | O95239 | P33174 | |||||||||||
| RefSeq (mRNA) | NM_012310 | NM_008446 | |||||||||||
| RefSeq (protein) | NP_036442 | NP_032472 | |||||||||||
| Location (UCSC) | Chr X: 69.51 – 69.64 Mb | Chr X: 100.63 – 100.73 Mb | |||||||||||
| PubMed search | |||||||||||||
Chromosome-associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene.[1][2]
Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division (Zhu and Jiang, 2005).[supplied by OMIM][2]
Interactions
KIF4A has been shown to interact with HMG20B[3] and DNMT3B.[4]
References
- ↑ Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenet Cell Genet 88 (1–2): 41–2. doi:10.1159/000015482. PMID 10773663.
- ↑ 2.0 2.1 "Entrez Gene: KIF4A kinesin family member 4A".
- ↑ Lee, Young Mi; Kim Wankee (Sep 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". Biochem. J. (England) 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
- ↑ Geiman, Theresa M; Sankpal Umesh T, Robertson Andrea K, Chen Yue, Mazumdar Manjari, Heale Jason T, Schmiesing John A, Kim Wankee, Yokomori Kyoko, Zhao Yingming, Robertson Keith D (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. (England) 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
Further reading
- Sekine Y, Okada Y, Noda Y et al. (1994). "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally". J. Cell Biol. 127 (1): 187–201. doi:10.1083/jcb.127.1.187. PMC 2120182. PMID 7929562.
- Yan RT, Wang SZ (1997). "Increased chromokinesin immunoreactivity in retinoblastoma cells". Gene 189 (2): 263–7. doi:10.1016/S0378-1119(96)00860-8. PMID 9168136.
- Tang Y, Winkler U, Freed EO et al. (1999). "Cellular motor protein KIF-4 associates with retroviral Gag". J. Virol. 73 (12): 10508–13. PMC 113106. PMID 10559369.
- Oh S, Hahn H, Torrey TA et al. (2000). "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein". Biochim. Biophys. Acta 1493 (1–2): 219–24. doi:10.1016/s0167-4781(00)00151-2. PMID 10978527.
- Lee YM, Lee S, Lee E et al. (2002). "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis". Biochem. J. 360 (Pt 3): 549–56. doi:10.1042/0264-6021:3600549. PMC 1222256. PMID 11736643.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lee YM, Kim W (2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". Biochem. J. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
- Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Lee YM, Kim W (2004). "Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells". Experimental & Molecular Medicine 36 (1): 93–7. doi:10.1038/emm.2004.13. PMID 15031677.
- Geiman TM, Sankpal UT, Robertson AK et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
- Kurasawa Y, Earnshaw WC, Mochizuki Y et al. (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMC 514520. PMID 15297875.
- Mazumdar M, Sundareshan S, Misteli T (2004). "Human chromokinesin KIF4A functions in chromosome condensation and segregation". J. Cell Biol. 166 (5): 613–20. doi:10.1083/jcb.200401142. PMC 2172419. PMID 15326200.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zhu C, Jiang W (2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 343–8. doi:10.1073/pnas.0408438102. PMC 544298. PMID 15625105.
- Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nousiainen M, Silljé HH, Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.