KIF3B
Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.[1][2]
Function
The protein encoded by this gene forms a heterotrimeric motor complex with kinesin family member 3A and KAP3 (kinesin accessory protein 3) to drive intra-flagellar transport and possibly to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. The heterotrimeric KIF3B/KIF3A/KAP3 motor protein is a member of the kinesin-2 subfamily of the kinesin superfamily.[2][3][4]
Interactions
KIF3B has been shown to interact with RAB4A.[5]
References
- ↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
- ↑ 2.0 2.1 "Entrez Gene: KIF3B kinesin family member 3B".
- ↑ Scholey JM (April 1996). "Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles". J. Cell Biol. 133 (1): 1–4. doi:10.1083/jcb.133.1.1. PMC 2120781. PMID 8601599.
- ↑ Lawrence, CJ; Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. (2004). "A standardized kinesin nomenclature". Journal of Cell Biology 167: 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732.
- ↑ Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM (July 2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin". Mol. Cell. Biol. 23 (14): 4892–900. doi:10.1128/MCB.23.14.4892-4900.2003. PMC 162221. PMID 12832475.
Further reading
- Yamazaki H, Nakata T, Okada Y, Hirokawa N (1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.". J. Cell Biol. 130 (6): 1387–99. doi:10.1083/jcb.130.6.1387. PMC 2120571. PMID 7559760.
- Nagata K, Puls A, Futter C et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
- Shimizu K, Shirataki H, Honda T et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.". J. Biol. Chem. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.
- Nonaka S, Tanaka Y, Okada Y et al. (1999). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.". Cell 95 (6): 829–37. doi:10.1016/S0092-8674(00)81705-5. PMID 9865700.
- Navarro E, Espinosa L, Adell T et al. (1999). "Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements.". Biochim. Biophys. Acta 1450 (3): 254–64. doi:10.1016/S0167-4889(99)00051-8. PMID 10395937.
- Whitehead JL, Wang SY, Bost-Usinger L et al. (1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina.". Exp. Eye Res. 69 (5): 491–503. doi:10.1006/exer.1999.0724. PMID 10548469.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Jimbo T, Kawasaki Y, Koyama R et al. (2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily.". Nat. Cell Biol. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492.
- Baker SA, Freeman K, Luby-Phelps K et al. (2003). "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia.". J. Biol. Chem. 278 (36): 34211–8. doi:10.1074/jbc.M300156200. PMID 12821668.
- Imamura T, Huang J, Usui I et al. (2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.". Mol. Cell. Biol. 23 (14): 4892–900. doi:10.1128/MCB.23.14.4892-4900.2003. PMC 162221. PMID 12832475.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Zhang Y, Hancock WO (2005). "The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds.". Biophys. J. 87 (3): 1795–804. doi:10.1529/biophysj.104.039842. PMC 1304584. PMID 15345558. (Retracted. If this is intentional, please replace
{{Retracted}}with{{Retracted|intentional=yes}}.) - Haraguchi K, Hayashi T, Jimbo T et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis.". J. Biol. Chem. 281 (7): 4094–9. doi:10.1074/jbc.M507028200. PMID 16298999.
- Wu Y, Dai XQ, Li Q et al. (2006). "Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.". Hum. Mol. Genet. 15 (22): 3280–92. doi:10.1093/hmg/ddl404. PMID 17008358.