KIF1B

Kinesin family member 1B
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsKIF1B ; CMT2; CMT2A; CMT2A1; HMSNII; KLP; NBLST1
External IDsOMIM: 605995 MGI: 108426 HomoloGene: 99835 ChEMBL: 5889 GeneCards: KIF1B Gene
Orthologs
SpeciesHumanMouse
Entrez2309516561
EnsemblENSG00000054523ENSMUSG00000063077
UniProtO60333Q60575
RefSeq (mRNA)NM_015074NM_001290995
RefSeq (protein)NP_055889NP_001277924
Location (UCSC)Chr 1:
10.27 – 10.44 Mb		Chr 4:
149.18 – 149.31 Mb
PubMed search

Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene.[1][2][3]

Clinical significance

It is associated with Charcot–Marie–Tooth disease 2A.

Interactions

KIF1B has been shown to interact with GIPC1.[4]

References

  1. ↑ Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N (Jun 2001). "Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta". Cell 105 (5): 587–97. doi:10.1016/S0092-8674(01)00363-4. PMID 11389829.
  2. ↑ Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A (May 2000). "Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2". Int J Oncol 16 (5): 907–16. doi:10.3892/ijo.16.5.907. PMID 10762626.
  3. ↑ "Entrez Gene: KIF1B kinesin family member 1B".
  4. ↑ Bunn, R C; Jensen M A; Reed B C (Apr 1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell 10 (4): 819–32. doi:10.1091/mbc.10.4.819. ISSN 1059-1524. PMC 25204. PMID 10198040.

Further reading

  • Nangaku M, Sato-Yoshitake R, Okada Y et al. (1995). "KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria". Cell 79 (7): 1209–20. doi:10.1016/0092-8674(94)90012-4. PMID 7528108.
  • Gong TL, Burmeister M, Lomax MI (1997). "The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36". Mamm. Genome 7 (10): 790–1. doi:10.1007/s003359900237. PMID 8854876.
  • Saito M, Hayashi Y, Suzuki T et al. (1998). "Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A". Neurology 49 (6): 1630–5. doi:10.1212/wnl.49.6.1630. PMID 9409358.
  • Nagase T, Ishikawa K, Miyajima N et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • Bunn RC, Jensen MA, Reed BC (1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell 10 (4): 819–32. doi:10.1091/mbc.10.4.819. PMC 25204. PMID 10198040.
  • Conforti L, Buckmaster EA, Tarlton A et al. (1999). "The major brain isoform of kif1b lacks the putative mitochondria-binding domain". Mamm. Genome 10 (6): 617–22. doi:10.1007/s003359901056. PMID 10341097.
  • Nagase T, Kikuno R, Ishikawa K et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Yang HW, Chen YZ, Takita J et al. (2001). "Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2". Oncogene 20 (36): 5075–83. doi:10.1038/sj.onc.1204456. PMID 11526494.
  • Mok H, Shin H, Kim S et al. (2002). "Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins". J. Neurosci. 22 (13): 5253–8. PMID 12097473.
  • Nakamura N, Miyake Y, Matsushita M et al. (2003). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles". J. Biochem. 132 (3): 483–91. doi:10.1093/oxfordjournals.jbchem.a003246. PMID 12204119.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
  • Chen YY, Takita J, Chen YZ et al. (2004). "Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma". Int. J. Oncol. 23 (3): 737–44. PMID 12888911.
  • Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
  • Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

External links