KIF14

Kinesin family member 14

Identifiers

KIF14 ; KIAA0042; MGC142302

External IDs

OMIM: 611279 MGI: 1098226 HomoloGene: 8916 ChEMBL: 5576 GeneCards: KIF14 Gene

Gene ontology
Molecular function	• microtubule motor activity • protein binding • ATP binding • microtubule binding • PDZ domain binding
Cellular component	• nucleus • cytoplasm • spindle • kinesin complex • microtubule • membrane
Biological process	• microtubule-based movement • metabolic process • regulation of cell adhesion • regulation of cell migration • regulation of Rap protein signal transduction • negative regulation of integrin activation • substrate adhesion-dependent cell spreading • establishment of protein localization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000118193

ENSMUSG00000041498

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
200.52 – 200.59 Mb

Chr 1:
136.47 – 136.53 Mb

PubMed search

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.^[1]^[2]

References

↑ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
↑ "Entrez Gene: KIF14 kinesin family member 14".

Further reading

Nakagawa T, Tanaka Y, Matsuoka E et al. (1997). "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9654–9. doi:10.1073/pnas.94.18.9654. PMC 23244. PMID 9275178.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Corson TW, Huang A, Tsao MS, Gallie BL (2005). "KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers.". Oncogene 24 (30): 4741–53. doi:10.1038/sj.onc.1208641. PMID 15897902.
Gruneberg U, Neef R, Li X et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis.". J. Cell Biol. 172 (3): 363–72. doi:10.1083/jcb.200511061. PMC 2063646. PMID 16431929.
Corson TW, Gallie BL (2006). "KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.". Int. J. Cancer 119 (5): 1088–94. doi:10.1002/ijc.21954. PMID 16570270.
Carleton M, Mao M, Biery M et al. (2006). "RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.". Mol. Cell. Biol. 26 (10): 3853–63. doi:10.1128/MCB.26.10.3853-3863.2006. PMC 1488988. PMID 16648480.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Bowles E, Corson TW, Bayani J et al. (2007). "Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.". Genes Chromosomes Cancer 46 (2): 118–29. doi:10.1002/gcc.20383. PMID 17099872.
Vasilescu J, Zweitzig DR, Denis NJ et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.". J. Proteome Res. 6 (1): 298–305. doi:10.1021/pr060438j. PMID 17203973.
Corson TW, Zhu CQ, Lau SK et al. (2007). "KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.". Clin. Cancer Res. 13 (11): 3229–34. doi:10.1158/1078-0432.CCR-07-0393. PMID 17545527.
Madhavan J, Coral K, Mallikarjuna K et al. (2007). "High expression of KIF14 in retinoblastoma: association with older age at diagnosis.". Invest. Ophthalmol. Vis. Sci. 48 (11): 4901–6. doi:10.1167/iovs.07-0063. PMID 17962437.