KIDINS220

Kinase D-interacting substrate, 220kDa

Identifiers

KIDINS220 ; ARMS

External IDs

OMIM: 615759 MGI: 1924730 HomoloGene: 14254 GeneCards: KIDINS220 Gene

Gene ontology
Molecular function	• PDZ domain binding
Cellular component	• late endosome • cytosol • membrane • integral component of membrane • protein complex
Biological process	• activation of MAPKK activity • in utero embryonic development • positive regulation of neuron projection development • cytoplasmic transport • nerve growth factor signaling pathway • neurotrophin TRK receptor signaling pathway • dendrite morphogenesis • cellular response to nerve growth factor stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000134313

ENSMUSG00000036333

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
8.87 – 8.98 Mb

Chr 12:
24.97 – 25.06 Mb

PubMed search

Kinase D-interacting substrate of 220 kDa is an enzyme that in humans is encoded by the KIDINS220 gene.^[1]^[2]^[3]

References

↑ Iglesias T, Cabrera-Poch N, Mitchell MP, Naven TJ, Rozengurt E, Schiavo G (Jan 2001). "Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D". J Biol Chem 275 (51): 40048–56. doi:10.1074/jbc.M005261200. PMID 10998417.
↑ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
↑ "Entrez Gene: KIDINS220 kinase D-interacting substance of 220 kDa".

Further reading

Kong H, Boulter J, Weber JL et al. (2001). "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors.". J. Neurosci. 21 (1): 176–85. PMID 11150334.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Riol-Blanco L, Iglesias T, Sánchez-Sánchez N et al. (2004). "The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells.". Eur. J. Immunol. 34 (1): 108–18. doi:10.1002/eji.200324640. PMID 14971036.
Arévalo JC, Yano H, Teng KK, Chao MV (2004). "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein.". EMBO J. 23 (12): 2358–68. doi:10.1038/sj.emboj.7600253. PMC 423292. PMID 15167895.
Chang MS, Arevalo JC, Chao MV (2004). "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein.". J. Neurosci. Res. 78 (2): 186–92. doi:10.1002/jnr.20262. PMID 15378608.
Bracale A, Cesca F, Neubrand VE et al. (2007). "Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.". Mol. Biol. Cell 18 (1): 142–52. doi:10.1091/mbc.E06-05-0453. PMC 1751333. PMID 17079733.