KDEL (amino acid sequence)
KDEL is a target peptide sequence in the amino acid structure of a protein which keeps it from secreting from the endoplasmic reticulum (ER) and is responsible for retrieval of ER lumenal proteins from the Golgi apparatus by retrograde transport.[1] It also targets proteins from other locations (such as the cytoplasm) to the ER. Proteins can only leave the ER after this sequence has been cleaved off.
The abbreviation KDEL is formed by the corresponding letters to each amino acid. This letter system was defined by the IUPAC and IUBMB in 1983, and is as follows:
- K—Lysine
- D—Aspartic acid
- E—Glutamic acid
- L—Leucine
Therefore, the sequence in three letter code is: Lys-Asp-Glu-Leu.
See also
- ER retention
- KKXX (amino acid sequence)
- Endoplasmic reticulum protein retention receptors
References
- ↑ Mariano Stornaiuolo, Lavinia V. Lotti, Nica Borgese, Maria-Rosaria Torrisi, Giovanna Mottola, Gianluca Martire, and Stefano Bonatti (March 2003). "KDEL and KKXX Retrieval Signals Appended to the Same Reporter Protein Determine Different Trafficking between Endoplasmic Reticulum, Intermediate Compartment, and Golgi Complex". Molecular Biology of the Cell 14 (3): 889–902. doi:10.1091/mbc.E02-08-0468.