KCNJ8

Potassium inwardly-rectifying channel, subfamily J, member 8
Identifiers
SymbolsKCNJ8 ; KIR6.1; uKATP-1
External IDsOMIM: 600935 MGI: 1100508 HomoloGene: 3654 IUPHAR: 441 ChEMBL: 4770 GeneCards: KCNJ8 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez376416523
EnsemblENSG00000121361ENSMUSG00000030247
UniProtQ15842P97794
RefSeq (mRNA)NM_004982NM_008428
RefSeq (protein)NP_004973NP_032454
Location (UCSC)Chr 12:
21.92 – 21.93 Mb		Chr 6:
142.56 – 142.57 Mb
PubMed search

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein.[1] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8".

Further reading

  • Kubo Y; Adelman JP; Clapham DE et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–526. doi:10.1124/pr.57.4.11. PMID 16382105.
  • Inagaki N; Tsuura Y; Namba N et al. (1995). "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart". J. Biol. Chem. 270 (11): 5691–5694. doi:10.1074/jbc.270.11.5691. PMID 7890693.
  • Inagaki N, Inazawa J, Seino S (1996). "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)". Genomics 30 (1): 102–104. doi:10.1006/geno.1995.0018. PMID 8595887.
  • Suzuki M; Kotake K; Fujikura K et al. (1998). "Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria". Biochem. Biophys. Res. Commun. 241 (3): 693–697. doi:10.1006/bbrc.1997.7891. PMID 9434770.
  • Erginel-Unaltuna N, Yang WP, Blanar MA (1998). "Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel". Gene 211 (1): 71–78. doi:10.1016/S0378-1119(98)00086-9. PMID 9573340.
  • Surah-Narwal S; Xu SZ; McHugh D et al. (1999). "Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A". Br. J. Pharmacol. 128 (3): 667–672. doi:10.1038/sj.bjp.0702862. PMC 1571700. PMID 10516647.
  • Tucker SJ, Ashcroft FM (1999). "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2". J. Biol. Chem. 274 (47): 33393–33397. doi:10.1074/jbc.274.47.33393. PMID 10559219.
  • Kono Y; Horie M; Takano M et al. (2001). "The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A". Pflugers Arch. 440 (5): 692–698. doi:10.1007/s004240000315. PMID 11007308.
  • Cui Y, Giblin JP, Clapp LH, Tinker A (2001). "A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 729–734. doi:10.1073/pnas.011370498. PMC 14656. PMID 11136227.
  • Liu Y; Ren G; O'Rourke B et al. (2001). "Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels". Mol. Pharmacol. 59 (2): 225–30. PMID 11160857.
  • Giblin JP, Cui Y, Clapp LH, Tinker A (2002). "Assembly limits the pharmacological complexity of ATP-sensitive potassium channels". J. Biol. Chem. 277 (16): 13717–13723. doi:10.1074/jbc.M112209200. PMID 11825905.
  • Vanoye CG; MacGregor GG; Dong K et al. (2002). "The carboxyl termini of K(ATP) channels bind nucleotides". J. Biol. Chem. 277 (26): 23260–23270. doi:10.1074/jbc.M112004200. PMID 11956191.
  • Miki T; Suzuki M; Shibasaki T et al. (2002). "Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1". Nat. Med. 8 (5): 466–472. doi:10.1038/nm0502-466. PMID 11984590.
  • Nakamura K, Hirano J, Itazawa S, Kubokawa M (2002). "Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells". Am. J. Physiol. Renal Physiol. 283 (4): F784–91. doi:10.1152/ajprenal.00023.2002. PMID 12217870.
  • Curley M; Cairns MT; Friel AM et al. (2003). "Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium". Mol. Hum. Reprod. 8 (10): 941–945. doi:10.1093/molehr/8.10.941. PMID 12356945.
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Singh H; Hudman D; Lawrence CL et al. (2004). "Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes". J. Mol. Cell. Cardiol. 35 (5): 445–459. doi:10.1016/S0022-2828(03)00041-5. PMID 12738227.
  • Insuk SO; Chae MR; Choi JW et al. (2003). "Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells". Int. J. Impot. Res. 15 (4): 258–266. doi:10.1038/sj.ijir.3901013. PMID 12934053.
  • Emanuele E; Falcone C; Carabela M et al. (2004). "Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion". Int. J. Mol. Med. 12 (4): 509–12. doi:10.3892/ijmm.12.4.509. PMID 12964027.
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.