KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a protein that in humans is encoded by the KCNJ12 gene.[1][2][3][4]
Function
This gene encodes an inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.[4]
Interactions
KCNJ12 has been shown to interact with LIN7C,[5][6] DLG4,[5][6] LIN7B,[5][6] DLG2,[5] DLG3,[5] DLG1,[5][6][7] APBA1,[5][6] LIN7A[5][6] and CASK.[5][6]
See also
References
- ↑ Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM (Mar 1995). "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circ Res 76 (3): 343–50. doi:10.1161/01.res.76.3.343. PMID 7859381.
- ↑ Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K (Nov 2002). "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Lett 531 (2): 250–254. doi:10.1016/S0014-5793(02)03512-3. PMID 12417321.
- ↑ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev 57 (4): 509–526. doi:10.1124/pr.57.4.11. PMID 16382105.
- ↑ 4.0 4.1 "Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12".
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
- ↑ Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (March 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell. Sci. 114 (Pt 5): 987–98. PMID 11181181.
Further reading
- Namba N; Inagaki N; Gonoi T et al. (1996). "Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2". FEBS Lett. 386 (2–3): 211–214. doi:10.1016/0014-5793(96)00445-0. PMID 8647284.
- Hugnot JP; Pedeutour F; Le Calvez C et al. (1997). "The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism". Genomics 39 (1): 113–116. doi:10.1006/geno.1996.4450. PMID 9027495.
- Gallagher PG, Forget BG (1998). "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene". J. Biol. Chem. 273 (3): 1339–1348. doi:10.1074/jbc.273.3.1339. PMID 9430667.
- Namba N; Mori R; Tanaka H et al. (1998). "The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2→p11.1". Cytogenet. Cell Genet. 79 (1–2): 85–87. doi:10.1159/000134688. PMID 9533018.
- Leonoudakis D; Mailliard W; Wingerd K et al. (2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell. Sci. 114 (Pt 5): 987–98. PMID 11181181.
- Preisig-Müller R; Schlichthörl G; Goerge T et al. (2002). "Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7774–7779. doi:10.1073/pnas.102609499. PMC 124349. PMID 12032359.
- Chen L; Kawano T; Bajic S et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8430–8435. doi:10.1073/pnas.122682899. PMC 123084. PMID 12034888.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Karkanis T, Li S, Pickering JG, Sims SM (2003). "Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery". Am. J. Physiol. Heart Circ. Physiol. 284 (6): H2325–34. doi:10.1152/ajpheart.00559.2002. PMID 12598232.
- Stonehouse AH; Grubb BD; Pringle JH et al. (2003). "Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies". J. Mol. Neurosci. 20 (2): 189–194. doi:10.1385/JMN:20:2:189. PMID 12794312.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Leonoudakis D; Conti LR; Radeke CM et al. (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–19063. doi:10.1074/jbc.M400284200. PMID 14960569.
- Leonoudakis D; Conti LR; Anderson S et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–22346. doi:10.1074/jbc.M400285200. PMID 15024025.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fang Y; Schram G; Romanenko VG et al. (2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". Am. J. Physiol., Cell Physiol. 289 (5): C1134–C1144. doi:10.1152/ajpcell.00077.2005. PMID 15958527.
- Kiesecker C; Zitron E; Scherer D et al. (2006). "Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1". J. Mol. Med. 84 (1): 46–56. doi:10.1007/s00109-005-0707-8. PMID 16258766.
External links
- Kir2.2 channel at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||