José Serrano
José Serrano may refer to:
- José E. Serrano (born 1943), Member of the U.S. House of Representatives for a portion of The Bronx, New York
- José M. Serrano (born 1972), his son, New York State Senator
- José Serrano (Ecuadorian politician), Ecuadorian political figure, currently Minister of the Interior
- José Serrano (composer) (1873–1941), Spanish zarzuela composer
- José Mariano Serrano (1788–1852), Bolivian member of the Congress of Tucumán
- José Manuel Serrano (born 1981), Spanish footballer
- José Serrano (pentathlete), Spanish pentathlete
- Rosso José Serrano, Columbian police officer