John Clayton

John Clayton may refer to:

• John Clayton (divine) (1709–1773), English cleric, Methodist and Jacobite
• John Clayton (minister) (1754–1843), English Independent
• John Clayton (painter) (1728–1800), English artist
• John M. Clayton (1796–1856), U.S. Senator from Delaware and U.S. Secretary of State
• John M. Clayton (Arkansas) (1840–1889), Arkansas carpetbagger, assassinated 1889
• John Clayton (sportswriter), writer and reporter for ESPN and SportsCenter
• John Clayton (bassist), American jazz bassist
• John Clayton (barrister) (died c. 1710), Original Fellow of the Royal Society
• John Clayton (botanist) (1694–1773), Colonial Virginia
• John Clayton (cricketer) (1857–1938), English cricketer
• John Clayton (footballer), Scottish footballer
• John Clayton (town clerk) (1792–1890), antiquarian and town clerk of Newcastle upon Tyne, England
• John Clayton, Lord Greystoke, birthname of the fictional character Tarzan
• John Bell Clayton and Martha Clayton (c.1907–1955) & (1915–1961), American writers
• John Clayton (actor) (1940–2003), Australian actor
• John Clayton Adams (1840–1906), English landscape artist
• John Clayton Allen (1860–1939), American politician
• Jack Clayton (1921–1995), British film director