James Otis

James Otis may refer to:

• James Otis, Sr. (1702–1778), Massachusetts lawyer and public official
• James Otis, Jr. (1725–1783), American revolutionary politician from Massachusetts
• James Otis (politician) (1826–1875), mayor of San Francisco, California
• James Otis (actor), American film and television actor
• James Otis Kaler (1848–1912) (pen name: James Otis), American journalist and author of children’s literature
• Jim Otis, American football player