James O'Brien
James O'Brien may refer to:
- James O'Brien (piper) (1823–1885), Irish musician
- Jay O'Brien (Virginia politician) (born 1951), Virginia politician
- James O'Brien (Canadian politician) (1836–1903), Canadian senator
- James Francis Xavier O'Brien (1828–1905) Irish rebel and UK MP
- James O'Brien (1695–1771), Irish nobleman and politician
- James O'Brien (1806–1881), Irish judge and UK MP for Limerick City 1854–1858
- James O'Brien (horticulturist) (1842–1930), winner of the Victoria Medal of Honour
- James O'Brien (New Zealand politician) (1874–1947), New Zealand politician
- James O'Brien (U.S. Congressman) (1841–1907), United States Representative from New York
- James O'Brien (radio presenter) (born 1972), British radio presenter and journalist
- James O'Brien (internet radio) (born 1973), founder and producer of RantMedia
- James O'Brien (footballer) (born 1987), Scots-born Irish football player
- James Bronterre O'Brien (1805–1864), Irish-born Chartist leader, reformer and journalist
- James F. O'Brien, American computer graphics researcher
- James H. O'Brien (1860–1924), United States Representative from New York
- James O'Brien, 3rd Marquess of Thomond (1769–1855), British naval officer
- James O'Brien (New Brunswick politician) (1824–1922), blacksmith and political figure in New Brunswick, Canada
- James O'Brien (hurler) (born 1983), Irish hurler
- James O'Brien, Australian musician, bassist for The Boat People
- James O'Brien (oceanographer)
See also
- Jamie O'Brien (disambiguation)
- Jim O'Brien (disambiguation)