JSC

JSC may refer to:

• Johnson State College, one of the Vermont State Colleges, and located at Johnson, Vermont, United States
• Joint-stock company
• Judicial Service Commission (disambiguation), the body tasked with appointing judges in several Commonwealth countries
• Julio Sanchez Cristo, a Latin American radio personality
• Jubilee Sports Centre, the former name of the Hong Kong Sports Institute
• Junior School Certificate, a public examination in Bangladesh
• Lyndon B. Johnson Space Center, the National Air and Space Administration's mission flight control and astronaut training facility at Houston, Texas, United States