JAZF1

JAZF zinc finger 1
Identifiers
SymbolsJAZF1 ; TIP27; ZNF802
External IDsOMIM: 606246 MGI: 2141450 HomoloGene: 18291 GeneCards: JAZF1 Gene
Orthologs
SpeciesHumanMouse
Entrez221895231986
EnsemblENSG00000153814ENSMUSG00000063568
UniProtQ86VZ6Q80ZQ5
RefSeq (mRNA)NM_175061NM_001168277
RefSeq (protein)NP_778231NP_001161749
Location (UCSC)Chr 7:
27.87 – 28.22 Mb
Chr 6:
52.77 – 53.07 Mb
PubMed search

Juxtaposed with another zinc finger protein 1 (JAZF1) also known as TAK1-interacting protein 27 (TIP27) or zinc finger protein 802 (ZNF802) is a protein that in humans is encoded by the JAZF1 gene.[1][2] Variants are associated with an increased risk of prostate cancer, an increased risk of type 2 diabetes, and an increased height.[3]

Function

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized[2]

References

  1. Adams MD, Soares MB, Kerlavage AR, Fields C, Venter JC (Nov 1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nat Genet 4 (4): 373–80. doi:10.1038/ng0893-373. PMID 8401585.
  2. 2.0 2.1 "Entrez Gene: JAZF1 JAZF zinc finger 1".
  3. Manolio TA; Guttmacher, Alan E.; Manolio, Teri A. (July 2010). "Genomewide Association Studies and Assessment of the Risk of Disease". N Engl J Med 363 (2): 166–176. doi:10.1056/NEJMra0905980. PMID 20647212.

Further reading