Isoxsuprine

Isoxsuprine[1]
Names
IUPAC name
4-{1-Hydroxy-2-[(1-methyl-2-phenoxyethyl)amino]propyl}phenol
Other names
Vasodilian, Duvadilan
Identifiers
ATC code C04AA01
395-28-8 Yes
ChEMBL ChEMBL1197051 
ChemSpider 3651 Yes
DrugBank DB08941 
Jmol-3D images Image
KEGG D08092 Yes
MeSH Isoxsuprine
PubChem 3783
Properties
Molecular formula
 C18H23NO3
Molar mass 301.38 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
  verify (what is: Yes/?)
Infobox references

Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator[2] in humans (under the trade name Duvadilan) and equines. Isoxsuprine is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle via beta-2 receptors.[3]

Use

In humans

Isoxsuprine it is used in humans for treatment of premature labor, i.e. a tocolytic,[4] and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud's phenomenon, and other conditions.[5]

Isoxsuprine may increase the heart rate, cause changes in blood pressure, and irritate the GI tract. It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and anesthetic drugs.

In horses

Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for laminitis and navicular disease, as its effects as a vasodilator are thought to increase circulation within the hoof to help counteract the problems associated with these conditions. Isoxsuprine is given orally, and many horses find the pills quite palatable.[6] Isoxsuprine is a prohibited class B drug in FEI-regulated competition, and is often prohibited by other equine associations. It may be detected in the urine for several weeks or months following administration. It is therefore important to check the drug-rules within an animal's given competitive organization, before administering the drug.

Because it is a vasodilator, it should not be used in horses that are bleeding, or in mares following foaling.

References

  1. ↑ Isoxsuprine - Compound Summary, PubChem.
  2. ↑ Gozo EG, Yebes RB (November 1984). "Hemodynamic effects of isoxsuprine in cardiac failure". Chest 86 (5): 736–40. doi:10.1378/chest.86.5.736. PMID 6488912.
  3. ↑ Falkay, G.; Kovács, L. (1986). "Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors". Journal of perinatal medicine 14 (2): 109–113. PMID 2874205.
  4. ↑ Giorgino, F. L.; Egan, C. G. (2010). "Use of isoxsuprine hydrochloride as a tocolytic agent in the treatment of preterm labour: A systematic review of previous literature". Arzneimittel-Forschung 60 (7): 415–420. doi:10.1055/s-0031-1296305. PMID 20712130.
  5. ↑ Drugs.com: Isoxsuprine
  6. ↑ Forney, Barbara C (2007). Equine Medications. Lexington, KY: Blood Horse Publications.