Isothiazolinone

Isothiazolinone

Names
IUPAC name 1,2-Thiazol-3-one
Other names Isothiazolin-3-one; 3(2H)-Isothiazolone
Identifiers
CAS Registry Number	1003-07-2 Y
ChemSpider	87509 N
InChI InChI=1S/C3H3NOS/c5-3-1-2-6-4-3/h1-2H,(H,4,5) N Key: MGIYRDNGCNKGJU-UHFFFAOYSA-N N InChI=1/C3H3NOS/c5-3-1-2-6-4-3/h1-2H,(H,4,5) Key: MGIYRDNGCNKGJU-UHFFFAOYAO
Jmol-3D images	Image Image
MeSH	C001490
PubChem	96917
SMILES O=C1NSC=C1 c1csnc1O
Properties
Chemical formula	C3H3NOS
Molar mass	101.127
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N verify (what is: Y/N?)
Infobox references

Isothiazolinone is a heterocyclic chemical compound. Derivatives of isothiazolinone are used as biocides, including:

• Methylisothiazolinone (MIT, MI)
• Chloromethylisothiazolinone (CMIT, CMI, MCI)
• Benzisothiazolinone (BIT)
• Octylisothiazolinone (OIT, OI)
• Dichlorooctylisothiazolinone (DCOIT, DCOI)

The derivative butylbenzisothiazolinone (BBIT) also exists, but does not have the same importance.

Applications

Isothiazolinones are antimicrobials used to control bacteria, fungi, and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems, wood preservation and antifouling agents. They are frequently used in personal care products such as shampoos and other hair care products, as well as certain paint formulations. Often, combinations of MIT and CMIT (known as Kathon CG) or MIT and BIT are used.

Biological implications

Together with their wanted function, controlling or killing microorganisms, isothiazolinones also have undesirable effects: They have a high aquatic toxicity and some derivatives (namely CMIT) can cause hypersensitivity by direct contact or via the air.

See also

• Methylisothiazolinone See other isothiazolinones

References