Interposed nucleus

Interposed nucleus
Details
Latin	nucleus interpositus anterior, nucleus interpositus posterior
Identifiers
NeuroLex ID	Interpositus Nucleus
Anatomical terms of neuroanatomy

The interposed nucleus is a deep nucleus of the cerebellum and is composed of the globose nuclei and the emboliform nuclei. It is located in the roof (dorsal aspect) of the fourth ventricle, lateral to the fastigial nucleus. It receives its afferent supply from the anterior lobe of the cerebellum and sends output via the superior cerebellar peduncle to the red nucleus.

The interposed nucleus is located in the paravermis of the cerebellum. It receives input from the ipsilateral cuneocerebellar tract and the dorsal spinocerebellar tract, which originate in the accessory cuneate nucleus and Clarke's nucleus, respectively. The interposed nucleus is responsible for coordinating agonist/antagonist muscle pairs, and therefore a lesion in this area causes tremor.

The interposed nucleus is smaller than the dentate but larger than the fastigial nucleus.

Function

Functionally, it modulates muscle stretch reflexes of proximal limb muscles.

External links

Anatomy of the cerebellum

Surface

Lobes	Anterior lobe Posterior lobe Horizontal fissure Flocculonodular lobe Flocculus Nodule Primary fissure

Medial/lateral	Vermis: anterior Central lobule Culmen Lingula posterior Folium Tuber Uvula Vallecula of cerebellum Hemisphere: anterior Alar central lobule posterior Biventer lobule Cerebellar tonsil

Grey matter

Deep cerebellar nuclei	Dentate interposed Emboliform Globose Fastigial

Cerebellar cortex	Molecular layer Stellate cell Basket cell Purkinje cell layer Purkinje cell Bergmann glia cell = Golgi epithelial cell Granule cell layer Golgi cell Granule cell Unipolar brush cell Fibers: Mossy fibers Climbing fiber Parallel fiber

White matter

Internal	Arbor vitae

Peduncles	Inferior (medulla): Dorsal spinocerebellar tract Olivocerebellar tract Cuneocerebellar tract Juxtarestiform body (Vestibulocerebellar tract) Middle (pons): Pontocerebellar fibers Superior (midbrain): Ventral spinocerebellar tract Dentatothalamic tract Trigeminocerebellar fibers

Index of the central nervous system

Description	Anatomy meninges cortex association fibers commissural fibers lateral ventricles basal ganglia diencephalon mesencephalon pons cerebellum medulla spinal cord tracts Physiology neutrotransmission enzymes intermediates Development

Disease	Cerebral palsy Meningitis Demyelinating diseases Seizures and epilepsy Headache Stroke Sleep Congenital Injury Neoplasms and cancer Other paralytic syndromes ALS Symptoms and signs head and neck eponymous lesions Tests CSF

Treatment	Procedures Drugs general anesthetics analgesics addiction epilepsy cholinergics migraine Parkinson's vertigo other

Brain and spinal cord: neural tracts and fasciculi

Sensory/
ascending

PCML

1°:	Pacinian corpuscle/Meissner's corpuscle → Posterior column (Gracile fasciculus/Cuneate fasciculus) → Gracile nucleus/Cuneate nucleus

2°:	→ sensory decussation/arcuate fibers (Posterior external arcuate fibers, Internal arcuate fibers) → Medial lemniscus/Trigeminal lemniscus → Thalamus (VPL, VPM)

3°:	→ Posterior limb of internal capsule → Postcentral gyrus

Anterolateral/
pain

Fast/lateral	1° (Free nerve ending → A delta fiber) → 2° (Anterior white commissure → Lateral and Anterior Spinothalamic tract → Spinal lemniscus → VPL of Thalamus) → 3° (Postcentral gyrus) → 4° (Posterior parietal cortex) 2° (Spinomesencephalic tract → Superior colliculus of Midbrain tectum)

Slow/medial	1° (Group C nerve fiber → Spinoreticular tract → Reticular formation) → 2° (MD of Thalamus) → 3° (Cingulate cortex)

Motor/
descending

Pyramidal

flexion: Primary motor cortex → Posterior limb of internal capsule → Decussation of pyramids → Corticospinal tract (Lateral, Anterior) → Neuromuscular junction

Extrapyramidal

flexion:	Primary motor cortex → Genu of internal capsule → Corticobulbar tract → Facial motor nucleus → Facial muscles

flexion:	Red nucleus → Rubrospinal tract

extension:	Vestibulocerebellum → Vestibular nuclei → Vestibulospinal tract

extension:	Vestibulocerebellum → Reticular formation → Reticulospinal tract

Midbrain tectum → Tectospinal tract → muscles of neck

Basal ganglia

direct:	1° (Motor cortex → Striatum) → 2° (GPi) → 3° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 4° (Thalamocortical radiations → Supplementary motor area) → 5° (Motor cortex)

indirect:	1° (Motor cortex → Striatum) → 2° (GPe) → 3° (Subthalamic fasciculus → Subthalamic nucleus) → 4° (Subthalamic fasciculus → GPi) → 5° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 6° (Thalamocortical radiations → Supplementary motor area) → 7° (Motor cortex)

nigrostriatal pathway:	Pars compacta → Striatum

Cerebellar

Afferent

Vestibular nuclei → Vestibulocerebellar tract → ICP → Cerebellum → Granule cell

Pontine nuclei → Pontocerebellar fibers → MCP → Deep cerebellar nuclei → Granule cell

Inferior olivary nucleus → Olivocerebellar tract → ICP → Hemisphere → Purkinje cell → Deep cerebellar nuclei

Efferent

Dentate nucleus in Lateral hemisphere/pontocerebellum → SCP → Dentatothalamic tract → Thalamus (VL) → Motor cortex

Interposed nucleus in Intermediate hemisphere/spinocerebellum → SCP → Reticular formation, or → Cerebellothalamic tract → Red nucleus → Thalamus (VL) → Motor cortex

Fastigial nucleus in Flocculonodular lobe/vestibulocerebellum → Vestibulocerebellar tract → Vestibular nuclei

Bidirectional:
Spinocerebellar

Unconscious proprioception	lower limb → 1° (muscle spindles → DRG) → 2° (Posterior thoracic nucleus → Dorsal/posterior spinocerebellar tract → ICP → Cerebellar vermis) upper limb → 1° (muscle spindles → DRG) → 2° (Accessory cuneate nucleus → Cuneocerebellar tract → ICP → Anterior lobe of cerebellum)

Reflex arc	lower limb → 1° (Golgi tendon organ) → 2° (Ventral/anterior spinocerebellar tract→ SCP → Cerebellar vermis) upper limb → 1° (Golgi tendon organ) → 2° (Rostral spinocerebellar tract → ICP → Cerebellum)

Index of the central nervous system

Description	Anatomy meninges cortex association fibers commissural fibers lateral ventricles basal ganglia diencephalon mesencephalon pons cerebellum medulla spinal cord tracts Physiology neutrotransmission enzymes intermediates Development

Disease	Cerebral palsy Meningitis Demyelinating diseases Seizures and epilepsy Headache Stroke Sleep Congenital Injury Neoplasms and cancer Other paralytic syndromes ALS Symptoms and signs head and neck eponymous lesions Tests CSF

Treatment	Procedures Drugs general anesthetics analgesics addiction epilepsy cholinergics migraine Parkinson's vertigo other