Interleukin 27 receptor, alpha subunit
Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.[1]
Function
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.[1]
Interactions
Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: IL27RA interleukin 27 receptor, alpha".
- ↑ Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW et al. (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
Further reading
- Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T et al. (1998). "Cloning and characterization of a novel class I cytokine receptor.". Biochem. Biophys. Res. Commun. 246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
- Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A et al. (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR.". Nature 407 (6806): 916–20. doi:10.1038/35038103. PMID 11057672.
- Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.". Immunity 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
- Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW et al. (2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
- Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF et al. (2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.". J. Immunol. 172 (4): 2225–31. doi:10.4049/jimmunol.172.4.2225. PMID 14764690.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Pradhan A, Lambert QT, Reuther GW (2008). "Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.". Proc. Natl. Acad. Sci. U.S.A. 104 (47): 18502–7. doi:10.1073/pnas.0702388104. PMC 2141806. PMID 18003935.
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