Integrin, beta 6

Integrin, beta 6
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolITGB6
External IDsOMIM: 147558 MGI: 96615 HomoloGene: 685 IUPHAR: 2460 ChEMBL: 4876 GeneCards: ITGB6 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez369416420
EnsemblENSG00000115221ENSMUSG00000026971
UniProtP18564Q9Z0T9
RefSeq (mRNA)NM_000888NM_001159564
RefSeq (protein)NP_000879NP_001153036
Location (UCSC)Chr 2:
160.96 – 161.13 Mb		Chr 2:
60.6 – 60.72 Mb
PubMed search

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene.[1][2][3]

Clinical effects

Mutations in ITGB6 cause amelogenesis imperfecta .[4]

Interactions

Integrin, beta 6 has been shown to interact with FHL2.[5]

References

  1. ↑ Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173.
  2. ↑ Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D (April 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". J Biol Chem 269 (9): 6940–8. PMID 8120056.
  3. ↑ "Entrez Gene: ITGB6 integrin, beta 6".
  4. ↑ Wang, S. K.; Choi, M; Richardson, A. S.; Reid, B. M.; Lin, B. P.; Wang, S. J.; Kim, J. W.; Simmer, J. P.; Hu, J. C. (2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
  5. ↑ Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

Further reading

  • Bowen JA, Hunt JS (2000). "The role of integrins in reproduction.". Proc. Soc. Exp. Biol. Med. 223 (4): 331–43. doi:10.1046/j.1525-1373.2000.22348.x. PMID 10721002.
  • Jiang WM, Jenkins D, Yuan Q et al. (1992). "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.". Int. Immunol. 4 (9): 1031–40. doi:10.1093/intimm/4.9.1031. PMID 1382574.
  • Busk M, Pytela R, Sheppard D (1992). "Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.". J. Biol. Chem. 267 (9): 5790–6. PMID 1532572.
  • Sheppard D, Rozzo C, Starr L et al. (1990). "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.". J. Biol. Chem. 265 (20): 11502–7. PMID 2365683.
  • Weinacker A, Ferrando R, Elliott M et al. (1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.". Am. J. Respir. Cell Mol. Biol. 12 (5): 547–56. doi:10.1165/ajrcmb.12.5.7537970. PMID 7537970.
  • Huang XZ, Chen A, Agrez M, Sheppard D (1995). "A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.". Am. J. Respir. Cell Mol. Biol. 13 (2): 245–51. doi:10.1165/ajrcmb.13.2.7626292. PMID 7626292.
  • Fernández-Ruiz E, Sánchez-Madrid F (1994). "Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31.". Genomics 21 (3): 638–40. doi:10.1006/geno.1994.1325. PMID 7959743.
  • Cone RI, Weinacker A, Chen A, Sheppard D (1994). "Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts.". Cell Adhes. Commun. 2 (2): 101–13. doi:10.3109/15419069409004430. PMID 8081887.
  • Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.". J. Biol. Chem. 271 (39): 24144–50. doi:10.1074/jbc.271.39.24144. PMID 8798654.
  • Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). "Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo.". Am. J. Physiol. 273 (1 Pt 1): L256–63. PMID 9252563.
  • Ostergaard K, Salter DM, Petersen J et al. (1998). "Expression of alpha and beta subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads.". Ann. Rheum. Dis. 57 (5): 303–8. doi:10.1136/ard.57.5.303. PMC 1752603. PMID 9741315.
  • Munger JS, Huang X, Kawakatsu H et al. (1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.". Cell 96 (3): 319–28. doi:10.1016/S0092-8674(00)80545-0. PMID 10025398.
  • Wixler V, Geerts D, Laplantine E et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
  • Arihiro K, Kaneko M, Fujii S et al. (2000). "Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma.". Breast Cancer 7 (1): 19–26. doi:10.1007/bf02967183. PMID 11029766.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Arend LJ, Smart AM, Briggs JP (2001). "Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development.". J. Am. Soc. Nephrol. 11 (12): 2297–305. PMID 11095652.
  • Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

External links