Inositol-hexakisphosphate kinase

Inositol-hexakisphosphate kinase
Identifiers
EC number 2.7.4.21
CAS number 176898-37-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Inositol-hexakisphosphate kinase (EC 2.7.4.21, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase) is an enzyme with system name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

(1) ATP + 1D-myo-inositol hexakisphosphate \rightleftharpoons ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
(2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate \rightleftharpoons ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)

Three mammalian isoforms are known to exist.

See also

References

  1. ↑ Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H. (1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr. Biol. 9: 1323–1326. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
  2. ↑ Schell, M.J., Letcher, A.J., Brearley, C.A., Biber, J., Murer, H. and Irvine, R.F. (1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Lett. 461: 169–172. doi:10.1016/S0014-5793(99)01462-3. PMID 10567691.
  3. ↑ Albert, C., Safrany, S.T., Bembenek, M.E., Reddy, K.M., Reddy, K.K., Falck, J.-R., Bröcker, M., Shears, S.B. and Mayr, G.W. (1997). "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". Biochem. J. 327: 553–560. PMC 1218829. PMID 9359429.

External links