Inosine kinase
| inosine kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.73 | ||||||||
| CAS number | 37237-46-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, an inosine kinase (EC 2.7.1.73) is an enzyme that catalyzes the chemical reaction
- ATP + inosine
ADP + IMP
Thus, the two substrates of this enzyme are ATP and inosine, whereas its two products are ADP and IMP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:inosine 5'-phosphotransferase. Other names in common use include inosine-guanosine kinase, and inosine kinase (phosphorylating). This enzyme participates in purine metabolism.
References
- Pierre KJ, LePage GA (1968). "Formation of inosine-5'-monophosphate by a kinase in cell-free extracts of Ehrlich ascites cells in vitro". Proc. Soc. Exp. Biol. Med. 127 (2): 432–40. doi:10.3181/00379727-127-32709. PMID 5645030.