Indoprofen
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| Systematic (IUPAC) name | |
|---|---|
|
2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]propanoic acid | |
| Clinical data | |
| |
| Oral | |
| Pharmacokinetic data | |
| Bioavailability | High (rapid and complete absorption) |
| Metabolism | Glucuronidation |
| Half-life | 2.3 hours |
| Excretion | Renal |
| Identifiers | |
31842-01-0  | |
| M01AE10 | |
| PubChem | CID 3718 |
| DrugBank |
DB08951  |
| ChemSpider |
3587 |
| UNII |
CPE46ZU14N |
| KEGG |
D04530 |
| ChEBI |
CHEBI:76162 |
| ChEMBL |
CHEMBL15870 |
| Chemical data | |
| Formula | C17H15NO3 |
| 281.306 g/mol | |
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SMILES
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| (what is this?) (verify) | |
Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]
A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]
References
- ↑ 1.0 1.1 Frazin, Natalie (March 9, 2005). "Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy". United States National Institute of Neurological Disorders and Stroke. Retrieved 2007-10-06.
- ↑ Lunn MR; Root DE; Martino AM et al. (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol 11 (11): 1489–1493. doi:10.1016/j.chembiol.2004.08.024. PMC 3160629. PMID 15555999.
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