Indobufen

Indobufen
Systematic (IUPAC) name


2-(4-(1-Oxoisoindolin-2-yl)phenyl)butanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	63610-08-2^Y
ATC code	B01AC10
PubChem	CID 107641
ChemSpider	96823^N
UNII	6T9949G4LZ^Y
KEGG	D07141^Y
ChEMBL	CHEMBL1765292^N
Chemical data
Formula	C₁₈H₁₇N O₃
Molecular mass	295.333 g/mol
SMILES O=C(O)C(c1ccc(cc1)N3C(=O)c2ccccc2C3)CC
InChI InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22) ^N Key:AYDXAULLCROVIT-UHFFFAOYSA-N ^N
N (what is this?) (verify)

Indobufen is a platelet aggregation inhibitor.^[1] It acts as a reversible cyclooxygenase inhibitor.^[2]

References

↑ The Merck Index, 12th Edition. 4991
↑ Eligini, Sonia; Violi, F; Banfi, C; Barbieri, SS; Brambilla, M; Saliola, M; Tremoli, E; Colli, S (2005). "Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism". Cardiovascular Research 69 (1): 218–226. doi:10.1016/j.cardiores.2005.07.013. PMID 16154551.

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Tirofiban Roxifiban Orbofiban

ADP receptor/P2Y₁₂ inhibitors	Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor

Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal

Thromboxane inhibitors	Thromboxane synthase inhibitors Dipyridamole (+Aspirin) Picotamide Receptor antagonists Terutroban^†

Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal

Other	Cloricromen Ditazole Vorapaxar

Vitamin K antagonists
(inhibit II, VII, IX, X)

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	Low molecular weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin^‡ Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide

Direct Xa inhibitors	Xabans Apixaban Betrixaban^§ Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban

Direct thrombin (IIa) inhibitors

Bivalent: Hirudin
- Bivalirudin
- Desirudin
- Lepirudin
Univalent: Argatroban
Dabigatran
Melagatran^‡
Ximelagatran^‡

Other

Thrombolytic drugs/
fibrinolytics

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Index of cells from bone marrow

Description	Immune system Cells Physiology coagulation proteins granule contents colony-stimulating heme and porphyrin metabolism intermediates

Disease	Red blood cell Monocyte and granulocyte Neoplasms and cancer Histiocytosis Symptoms and signs eponymous Blood tests findings

Treatment	Transfusion Drugs thrombosis bleeding other