Immunosignature

Immunosignaturing is a medical diagnostic test which uses arrays of random-sequence peptides to associate antibodies in a blood sample with a disease. Patent: "Compound Arrays for Sample Profiling", WO 2,010,148,365, inventor(s): Johnston, Stephen A; Stafford, Phillip.

References

• "2007 GELSS Symposium Abstracts". Arizona State University. 2007. p. 5. Retrieved 8 April 2010. 

• Legutki JB, Magee DM, Stafford P, Johnston SA. "A general method for characterization of humoral immunity induced by a vaccine or infection". doi: 10.1016/j.vaccine.2010.04.061 Vaccine, 2010.

• Brown P, Stafford P, Johnston SA, Dinu Valentin: "Statistical Methods for Analyzing Immunosignatures". BMC Bioinformatics, 12:349, doi:10.1186/1471-2105-12-349, 2011.

• Restrepo L, Stafford P, Magee DM, Johnston SA. "Application of immunosignatures to the assessment of Alzheimer's disease". Annals of Neurology doi:10.1002/ana.22405. 2011.

• Halperin RF, Stafford P, Johnston SA. "Exploring antibody recognition of sequence space through random-sequence microarrays". Molecular and Cellular Proteomics doi:10.1074/mcp.M110.000786. 2011.

• Stafford P, Johnston SA. "Microarray Technology Displays the Complexities of the Humoral Immune Response". Expert Reviews in Molecular Diagnostics 11(1):5-8. 2011

• Halperin RF, Stafford P, Emery JS, Navalkar KA, Johnston SA: "GuiTope: An Application for Mapping Random-Sequence Peptides to Protein Sequences", BMC Bioinformaticsˆ, 13:1, doi:10.1186/1471-2105-13-1. 2012.

• Kukreja M, Johnston SA, Stafford P: "Immunosignaturing Microarrays Distinguish Antibody Profiles of Related Pancreatic Diseases", Journal of Proteomics and Bioinformatics, doi:10.4172/jpb.S6-001. 2012.

• Stafford P, Halperin R, Legutki JB, Magee DM, Galgiani J, Johnston SA: "Physical Characterization of the ‘Immunosignaturing Effect", doi:10.1074/mcp.M111.011593, Molecular and Cellular Proteomics. 2012.

• Kukreja M, Johnston SA, Stafford P: "Comparative Study of Classification Algorithms for Immunosignaturing Data", doi:10.1186/1471-2105-13-139, BMC Bioinformatics. 2012.

• Hughes A, Cichacz Z, Scheck A, Coons SW, Johnston SA, Stafford P: "Immunosiganturing Can Detect Products from Molecular Markers in Brain Cancer", doi:10.1371/journal.pone.0040201, PLoS ONE, 2012.

• Chase BA, Johnston SA and Legutki JB. "Evaluation of Biological Sample Preparation for Immunosignature-Based Diagnostics", doi:10.1128/CVI.05667-11, Clinical and Vaccine Immunology, 2012.

• Kroening K, Johnston SA, Legutki JB. "Autoreactive antibodies raised by self derived de novo peptides can identify unrelated antigens on protein microarrays", doi:10.1016/j.yexmp.2012.03.002, Experimental and Molecular Pathology, 2012.

• Restrepo L, Stafford P, Johnston SA. "Feasibility of an early Alzheimer's disease immunosignature diagnostic test", doi:10.1016/j.jneuroim.2012.09.014, Journal of Neuroimmunology, 2012.

• Sykes K., Legutki JB, Stratford P. "Immunosignaturing: a critical review", doi: 10.1016/j.tibtech.2012.10.012, Cell Press, 2012.

• Johnston SA "Healthcare by Mail", http://www.zocalopublicsquare.org/2011/09/12/dear-john-you-have-psoriasis/ideas/nexus/

• Legutki JB, Johnston SA: "Immunosignatures can predict vaccine efficacy", Proceedings of the National Academy of Sciences doi:10.1073/pnas.130939011, PNAS, 2013.

• Navalkar KA, Johnston SA, Woodbury N, Galgiani J, Magee DM, Chicacz Z, Stafford P. "Application of Immunosignatures to Diagnosis of Valley Fever", doi:10.1128/CVI.00228-14, Clinical and Vaccine Immunology, 2014.

• Williams S, Stafford P, Hoffman SA. "Diagnosis and Early Detection of CNS-SLE in MRL/lpr Mice Using Peptide Microarrays", doi:10.1186/1471-2172-15-23, BMC Immunology, 2014.

• Stafford P, Cichacz Z, Woodbury N, Johnston SA. "Immunosignature System for Diagnosis of Cancer", doi: 10.1073/pnas.1409432111, PNAS, 2014.

• Legutki JB, Zhao ZG, Greving M, Woodbury N, Johnston SA, Stafford P. "Scalable High-Density Peptide Arrays for Comprehensive Health Monitoring", doi:10.1038/ncomms5785, Nature Communications, 2014.

Commercialization

HealthTell acquired the Immunosignature patent in 2012 and is commercializing the human diagnosis capabilities using high throughput manufacturing. For more information: http://www.healthtell.com/