Immunoglobulin heavy constant alpha 1

Immunoglobulin heavy constant alpha 1
Available structures
PDB Human UniProt search: PDBe, RCSB
Identifiers
SymbolsIGHA1 ; IgA1
External IDsOMIM: 146900 GeneCards: IGHA1 Gene
Orthologs
SpeciesHumanMouse
Entrez3493n/a
Ensembln/an/a
UniProtP01876n/a
RefSeq (mRNA)n/an/a
RefSeq (protein)n/an/a
Location (UCSC)n/an/a
PubMed searchn/a

Ig alpha-1 chain C region is a protein that in humans is encoded by the IGHA1 gene.[1]

References

  1. ↑ "Entrez Gene: IGHA1 immunoglobulin heavy constant alpha 1".

Further reading

  • Kerr MA (1990). "The structure and function of human IgA.". Biochem. J. 271 (2): 285–96. PMC 1149552. PMID 2241915.
  • Putnam FW, Liu YS, Low TL (1979). "Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain.". J. Biol. Chem. 254 (8): 2865–74. PMID 107164.
  • Yang C, Kratzin H, Götz H, Hilschmann N (1980). "[Rule of antibody structure. Primary structure of a human monoclonal IgA-immunoglobulin (myeloma protein Tro). VII. Purification and characterization of the disulfide bridges]". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1919–40. PMID 393607.
  • Kratzin H, Altevogt P, Ruban E et al. (1975). "[The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 356 (8): 1337–42. PMID 809331.
  • Flanagan JG, Lefranc MP, Rabbitts TH (1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences.". Cell 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489.
  • Takahashi N, Ueda S, Obata M et al. (1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family.". Cell 29 (2): 671–9. doi:10.1016/0092-8674(82)90183-0. PMID 6811139.
  • Calero M, Escribano J, Grubb A, Méndez E (1994). "Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex.". J. Biol. Chem. 269 (1): 384–9. PMID 7506257.
  • Pleass RJ, Dunlop JI, Anderson CM, Woof JM (1999). "Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89.". J. Biol. Chem. 274 (33): 23508–14. doi:10.1074/jbc.274.33.23508. PMID 10438530.
  • McLean GR, Nakouzi A, Casadevall A, Green NS (2001). "Human and murine immunoglobulin expression vector cassettes.". Mol. Immunol. 37 (14): 837–45. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305.
  • Gala FA, Morrison SL (2002). "The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1.". J. Biol. Chem. 277 (32): 29005–11. doi:10.1074/jbc.M203258200. PMID 12023968.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kristiansen TZ, Bunkenborg J, Gronborg M et al. (2005). "A proteomic analysis of human bile.". Mol. Cell Proteomics 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.
  • Senior BW, Woof JM (2005). "Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases.". Infect. Immun. 73 (3): 1515–22. doi:10.1128/IAI.73.3.1515-1522.2005. PMC 1064975. PMID 15731049.
  • Wines BD, Willoughby N, Fraser JD, Hogarth PM (2006). "A competitive mechanism for staphylococcal toxin SSL7 inhibiting the leukocyte IgA receptor, Fc alphaRI, is revealed by SSL7 binding at the C alpha2/C alpha3 interface of IgA.". J. Biol. Chem. 281 (3): 1389–93. doi:10.1074/jbc.M509334200. PMID 16293625.
  • Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Almogren A, Furtado PB, Sun Z et al. (2006). "Purification, properties and extended solution structure of the complex formed between human immunoglobulin A1 and human serum albumin by scattering and ultracentrifugation.". J. Mol. Biol. 356 (2): 413–31. doi:10.1016/j.jmb.2005.11.060. PMID 16376934.
  • Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Geng LY, Shi ZZ, Dong Q et al. (2007). "Expression of SNC73, a transcript of the immunoglobulin alpha-1 gene, in human epithelial carcinomas.". World J. Gastroenterol. 13 (16): 2305–11. doi:10.3748/wjg.v13.i16.2305. PMID 17511028.