Idrocilamide

Idrocilamide
Systematic (IUPAC) name
N-(2-hydroxyethyl)-3-phenyl-2-propenamide
Clinical data
Trade names Talval, Srilane, Relaxnova, Brolitène
AHFS/Drugs.com International Drug Names
Topical
Identifiers
6961-46-2 Yes
M02AX05
PubChem CID 1550874
ChemSpider 1267352 
UNII 6C816LUB1O Yes
Chemical data
Formula C11H13NO2
191.226 g/mol
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Idrocilamide (trade names Talval, Srilane, Relaxnova, Brolitène[1][2]) is a medication with skeletal muscle relaxant[3] and anti-inflammatory actions[4] used as a topical cream to treat lumbago and other kinds of muscular pain;[5] it is available on prescription or over-the-counter in France and various other countries.[1]

Interactions

Idrocilamide has been reported to be a potent inhibitor of the metabolism of caffeine.[6][7]

References

  1. ↑ 1.0 1.1 Drugs.com: International Drug Names
  2. ↑ Drugfuture.com: Idrocilamide
  3. ↑ Bouron, A.; Rivet, M.; Nasri-Sebdani, M.; Guillemain, J.; Durbin, P.; Guerrier, D.; Raymond, G. (1990). "The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers". Canadian journal of physiology and pharmacology 68 (12): 1503–1509. doi:10.1139/y90-228. PMID 2085796.
  4. ↑ Bannwarth B, Le Huec JC, Vinçon G et al. (December 1993). "[Tissue and systemic diffusion of idrocilamide after cutaneous administration]". Rev Rhum Ed Fr (in French) 60 (12): 932–6. PMID 8012322.
  5. ↑ Stehman, M.; Lehert, P. (1990). "Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago". Acta Belgica. Medica physica : organe officiel de la Societe royale belge de medecine physique et de rehabilitation 13 (1): 29–32. PMID 2140002.
  6. ↑ Carrillo JA, Benitez J (August 2000). "Clinically significant pharmacokinetic interactions between dietary caffeine and medications". Clin Pharmacokinet 39 (2): 127–53. doi:10.2165/00003088-200039020-00004. PMID 10976659.
  7. ↑ Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC (January 1980). "Inhibition by idrocilamide of the disposition of caffeine". Eur. J. Clin. Pharmacol. 17 (1): 37–43. doi:10.1007/bf00561675. PMID 7371698.