ITGA8

Integrin, alpha 8

Identifiers

External IDs

OMIM: 604063 MGI: 109442 HomoloGene: 37396 IUPHAR: 2447 GeneCards: ITGA8 Gene

Gene ontology
Molecular function	• metal ion binding
Cellular component	• plasma membrane • integrin complex • postsynaptic density • dendritic spine membrane • integrin alpha8-beta1 complex • perikaryon • apical part of cell
Biological process	• metanephros development • cell-matrix adhesion • integrin-mediated signaling pathway • brain development • memory • single organismal cell-cell adhesion • cell projection organization • extracellular matrix organization • positive regulation of transforming growth factor beta receptor signaling pathway • inner ear morphogenesis • establishment of protein localization • smooth muscle tissue development • positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
15.56 – 15.76 Mb

Chr 2:
12.11 – 12.3 Mb

PubMed search

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^[1]^[2]

References

↑ Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci 108 (2): 537–44. PMID 7768999.
↑ "Entrez Gene: ITGA8 integrin, alpha 8".

Schnapp LM, Hatch N, Ramos DM et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467.
Denda S, Müller U, Crossin KL et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.". Biochemistry 37 (16): 5464–74. doi:10.1021/bi9727489. PMC 2710129. PMID 9548928.
Hartner A, Schöcklmann H, Pröls F et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.". Kidney Int. 56 (4): 1468–80. doi:10.1046/j.1523-1755.1999.00662.x. PMID 10504498.
Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1.". Nat. Genet. 24 (4): 424–8. doi:10.1038/74286. PMID 10742111.
Brandenberger R, Schmidt A, Linton J et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney.". J. Cell Biol. 154 (2): 447–58. doi:10.1083/jcb.200103069. PMC 2150762. PMID 11470831.
Ljubimov AV, Saghizadeh M, Pytela R et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.". J. Histochem. Cytochem. 49 (11): 1341–50. doi:10.1177/002215540104901102. PMID 11668187.
Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8090–5. doi:10.1073/pnas.122229199. PMC 123025. PMID 12060755.
Lu M, Munger JS, Steadele M et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1.". J. Cell. Sci. 115 (Pt 23): 4641–8. doi:10.1242/jcs.00145. PMID 12415008.
Bieritz B, Spessotto P, Colombatti A et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.". Kidney Int. 64 (1): 119–27. doi:10.1046/j.1523-1755.2003.00057.x. PMID 12787402.
Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Ekwa-Ekoka C, Diaz GA, Carlson C et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8).". Matrix Biol. 23 (7): 487–96. doi:10.1016/j.matbio.2004.08.005. PMID 15579315.
Scherberich A, Tucker RP, Degen M et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.". Oncogene 24 (9): 1525–32. doi:10.1038/sj.onc.1208342. PMID 15592496.

External links

ITGA8 Info with links in the Cell Migration Gateway

Integrins

Alpha

Beta

Dimers

Cytoadhesin receptor:	Integrin alpha6beta4 Glycoprotein IIb/IIIa ITGA2B+ITGB3

Fibrinogen receptor:	Macrophage-1 antigen CD11b+CD18

Fibronectin receptor:	Integrin alpha2beta1 Integrin alpha4beta1 Integrin alpha5beta1

Leukocyte-adhesion receptor:	LFA-1 CD11a+CD18 Macrophage-1 antigen CD11b+CD18 Integrin alphaXbeta2 CD11c+CD18

Very late antigen receptor:	Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1 VLA-4 CD49d+CD29 Alpha-5 beta-1 Integrin alpha6beta1

Vitronectin receptor:	Alpha-v beta-3 Alpha-v beta-5

see also cell surface receptor deficiencies

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

ITGA8

References

Further reading

External links