ITGA7
Integrin alpha-7 is a protein that in humans is encoded by the ITGA7 gene.[1][2]
Function
ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.[2]
Interactions
ITGA7 has been shown to interact with FHL2[3] and FHL3.[3]
See also
References
- ↑ Wang W, Wu W, Desai T, Ward DC, Kaufman SJ (Aug 1995). "Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families". Genomics 26 (3): 568–70. doi:10.1016/0888-7543(95)80176-M. PMID 7607681.
- ↑ 2.0 2.1 "Entrez Gene: ITGA7 integrin, alpha 7".
- ↑ 3.0 3.1 Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R et al. (Jul 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962. Vancouver style error (help)
Further reading
- Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain". Matrix Biol. 16 (4): 185–93. doi:10.1016/S0945-053X(97)90007-X. PMID 9402008.
- Song WK, Wang W, Foster RF, Bielser DA, Kaufman SJ (1992). "H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis". J. Cell Biol. 117 (3): 643–57. doi:10.1083/jcb.117.3.643. PMC 2289453. PMID 1315319.
- Kramer RH, Vu MP, Cheng YF, Ramos DM, Timpl R, Waleh N (1992). "Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes". Cell Regul. 2 (10): 805–17. doi:10.1091/mbc.2.10.805. PMC 361876. PMID 1839357.
- Song WK, Wang W, Sato H, Bielser DA, Kaufman SJ (1994). "Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases". J. Cell. Sci. 106 (4): 1139–52. PMID 8126096.
- Ziober BL, Vu MP, Waleh N, Crawford J, Lin CS, Kramer RH (1994). "Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development". J. Biol. Chem. 268 (35): 26773–83. PMID 8253814.
- Martin PT, Kaufman SJ, Kramer RH, Sanes JR (1996). "Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction". Dev. Biol. 174 (1): 125–39. doi:10.1006/dbio.1996.0057. PMID 8626012.
- Ziober BL, Chen Y, Kramer RH (1997). "The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain". Mol. Biol. Cell 8 (9): 1723–34. doi:10.1091/mbc.8.9.1723. PMC 305732. PMID 9307969.
- Basora N, Vachon PH, Herring-Gillam FE, Perreault N, Beaulieu JF (1997). "Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation". Gastroenterology 113 (5): 1510–21. doi:10.1053/gast.1997.v113.pm9352853. PMID 9352853.
- Mayer U, Saher G, Fässler R, Bornemann A, Echtermeyer F, von der Mark H et al. (1997). "Absence of integrin alpha 7 causes a novel form of muscular dystrophy". Nat. Genet. 17 (3): 318–23. doi:10.1038/ng1197-318. PMID 9354797. Vancouver style error (help)
- Leung E, Lim SP, Berg R, Yang Y, Ni J, Wang SX et al. (1998). "A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing". Biochem. Biophys. Res. Commun. 243 (1): 317–25. doi:10.1006/bbrc.1998.8092. PMID 9473524.
- Zolkiewska A, Thompson WC, Moss J (1998). "Interaction of integrin alpha 7 beta 1 in C2C12 myotubes and in solution with laminin". Exp. Cell Res. 240 (1): 86–94. doi:10.1006/excr.1998.4002. PMID 9570924.
- Hayashi YK, Chou FL, Engvall E, Ogawa M, Matsuda C, Hirabayashi S et al. (1998). "Mutations in the integrin alpha7 gene cause congenital myopathy". Nat. Genet. 19 (1): 94–7. doi:10.1038/ng0598-94. PMID 9590299.
- Vignier N, Moghadaszadeh B, Gary F, Beckmann J, Mayer U, Guicheney P (1999). "Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7)". Biochem. Biophys. Res. Commun. 260 (2): 357–64. doi:10.1006/bbrc.1999.0916. PMID 10403775.
- Tachibana I, Hemler ME (1999). "Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance". J. Cell Biol. 146 (4): 893–904. doi:10.1083/jcb.146.4.893. PMC 2156130. PMID 10459022.
- Schöber S, Mielenz D, Echtermeyer F, Hapke S, Pöschl E, von der Mark H et al. (2000). "The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins". Exp. Cell Res. 255 (2): 303–13. doi:10.1006/excr.2000.4806. PMID 10694445. Vancouver style error (help)
- Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
- Burkin DJ, Kim JE, Gu M, Kaufman SJ (2000). "Laminin and alpha7beta1 integrin regulate agrin-induced clustering of acetylcholine receptors". J. Cell. Sci. 113 (16): 2877–86. PMID 10910772.
- Vizirianakis IS, Yao CC, Chen Y, Ziober BL, Tsiftsoglou AS, Kramer RH (2001). "Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin". Arch. Biochem. Biophys. 385 (1): 108–16. doi:10.1006/abbi.2000.2134. PMID 11361006.
External links
- ITGA7 Info with links in the Cell Migration Gateway
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