IRF7

Interferon regulatory factor 7
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2O61
Identifiers
Symbols	IRF7 ; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H
External IDs	OMIM: 605047 MGI: 1859212 HomoloGene: 128624 GeneCards: IRF7 Gene
Gene ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity • DNA binding • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • endosome membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • regulation of adaptive immune response • transcription from RNA polymerase II promoter • cellular response to DNA damage stimulus • response to virus • immunoglobulin mediated immune response • establishment of viral latency • cytokine-mediated signaling pathway • regulation of type I interferon production • positive regulation of type I interferon production • interferon-alpha production • interferon-beta production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • regulation of MyD88-dependent toll-like receptor signaling pathway • regulation of MyD88-independent toll-like receptor signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 9 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • MDA-5 signaling pathway • innate immune response • type I interferon biosynthetic process • regulation of monocyte differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of immune response • interferon-gamma-mediated signaling pathway • type I interferon signaling pathway • positive regulation of type I interferon-mediated signaling pathway • negative regulation of macrophage apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3665	54123
Ensembl	ENSG00000185507	ENSMUSG00000025498
UniProt	Q92985	P70434
RefSeq (mRNA)	NM_001572	NM_001252600
RefSeq (protein)	NP_001563	NP_001239529
Location (UCSC)	Chr 11: 0.61 – 0.62 Mb	Chr 7: 141.26 – 141.27 Mb
PubMed search

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

Function

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes.^[1] Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.^[2]

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response.^[3] Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.^[4]

Interactions

IRF7 has been shown to interact with IRF3.^[5]

See also

• Interferon regulatory factors

References

Further reading

External links

• IRF7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.