IRAK4
| interleukin-1 receptor-associated kinase 4 | |
|---|---|
| Identifiers | |
| Symbol | IRAK4 |
| Entrez | 51135 |
| HUGO | 17967 |
| OMIM | 606883 |
| RefSeq | NM_016123 |
| UniProt | Q9NWZ3 |
| Other data | |
| Locus | Chr. 12 q12 |
IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors.
Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.
Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations
External links
- IRAK4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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