IRAK3

Interleukin-1 receptor-associated kinase 3

Identifiers

IRAK3 ; ASRT5; IRAKM

External IDs

OMIM: 604459 MGI: 1921164 HomoloGene: 36215 IUPHAR: 2044 ChEMBL: 5081 GeneCards: IRAK3 Gene

Gene ontology
Molecular function	• magnesium ion binding • protein serine/threonine kinase activity • ATP binding • protein homodimerization activity • protein heterodimerization activity
Cellular component	• nucleus • cytoplasm
Biological process	• negative regulation of cytokine-mediated signaling pathway • MyD88-dependent toll-like receptor signaling pathway • protein phosphorylation • response to virus • positive regulation of macrophage tolerance induction • negative regulation of macrophage cytokine production • cytokine-mediated signaling pathway • negative regulation of NF-kappaB transcription factor activity • response to peptidoglycan • response to lipopolysaccharide • negative regulation of interleukin-12 production • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production • negative regulation of toll-like receptor signaling pathway • negative regulation of protein catabolic process • negative regulation of protein complex disassembly • regulation of protein complex disassembly • response to exogenous dsRNA • negative regulation of MAP kinase activity • negative regulation of innate immune response • protein autophosphorylation • positive regulation of NF-kappaB transcription factor activity • interleukin-1-mediated signaling pathway • response to interleukin-1
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000090376

ENSMUSG00000020227

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
66.58 – 66.65 Mb

Chr 10:
120.14 – 120.2 Mb

PubMed search

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.^[1]^[2]

References

↑ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J Biol Chem 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
↑ "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".

Further reading

Rosati O, Martin MU (2002). "Identification and characterization of murine IRAK-M.". Biochem. Biophys. Res. Commun. 293 (5): 1472–7. doi:10.1016/S0006-291X(02)00411-4. PMID 12054681.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Escoll P, del Fresno C, García L et al. (2004). "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients". Biochem. Biophys. Res. Commun. 311 (2): 465–72. doi:10.1016/j.bbrc.2003.10.019. PMID 14592437.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
del Fresno C, Otero K, Gómez-García L et al. (2005). "Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4". J. Immunol. 174 (5): 3032–40. doi:10.4049/jimmunol.174.5.3032. PMID 15728517.
Su J, Xie Q, Wilson I, Li L (2007). "Differential regulation and role of Interleukin-1 Receptor Associated Kinase-M in innate immunity signaling". Cell. Signal. 19 (7): 1596–601. doi:10.1016/j.cellsig.2007.02.009. PMC 1978187. PMID 17379480.
Balaci L, Spada MC, Olla N et al. (2007). "IRAK-M Is Involved in the Pathogenesis of Early-Onset Persistent Asthma". Am. J. Hum. Genet. 80 (6): 1103–14. doi:10.1086/518259. PMC 1867098. PMID 17503328.
Weersma RK, Oostenbrug LE, Nolte IM et al. (2007). "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases". Scand. J. Gastroenterol. 42 (7): 827–33. doi:10.1080/00365520601114024. PMID 17558906.
van 't Veer C, van den Pangaart PS, van Zoelen MA et al. (2007). "Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model". J. Immunol. 179 (10): 7110–20. doi:10.4049/jimmunol.179.10.7110. PMID 17982103.