IQGAP2
| IQ motif containing GTPase activating protein 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbol | IQGAP2 | ||||||||||||
| External IDs | OMIM: 605401 HomoloGene: 101543 GeneCards: IQGAP2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10788 | 544963 | |||||||||||
| Ensembl | ENSG00000145703 | ENSMUSG00000021676 | |||||||||||
| UniProt | Q13576 | Q3UQ44 | |||||||||||
| RefSeq (mRNA) | NM_001285460 | NM_027711 | |||||||||||
| RefSeq (protein) | NP_001272389 | NP_081987 | |||||||||||
| Location (UCSC) | Chr 5: 75.7 – 76 Mb | Chr 13: 95.63 – 95.89 Mb | |||||||||||
| PubMed search | |||||||||||||
Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.[1][2]
Function
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.[2]
Interactions
IQGAP2 has been shown to interact with CDC42[1] and RAC1.[1]
References
- ↑ 1.0 1.1 1.2 Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L et al. (Sep 1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases". Mol. Cell. Biol. 16 (9): 4869–78. PMC 231489. PMID 8756646.
- ↑ 2.0 2.1 "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2".
Further reading
- McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2". J. Biol. Chem. 271 (36): 21732–7. doi:10.1074/jbc.271.36.21732. PMID 8702968.
- Yin H, Morioka H, Towle CA, Vidal M, Watanabe T, Weissbach L (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine 15 (3): 122–37. doi:10.1006/cyto.2001.0891. PMID 11554782.
- Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (2002). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
- Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF (2003). "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization". Blood 101 (8): 3021–8. doi:10.1182/blood-2002-09-2807. PMID 12515716.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR et al. (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Chew CS, Okamoto CT, Chen X, Qin HY (2005). "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376–87. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
- Wang H, Huo R, Xu M, Lu L, Xu Z, Li J et al. (2005). "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis". DNA Seq. 15 (5-6): 319–25. doi:10.1080/10425170400009012. PMID 15621655.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.