ILKAP
| Integrin-linked kinase-associated serine/threonine phosphatase | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ILKAP ; ILKAP2; ILKAP3; PP2C-DELTA | ||||||||||||
| External IDs | MGI: 1914694 HomoloGene: 31525 ChEMBL: 2290 GeneCards: ILKAP Gene | ||||||||||||
| EC number | 3.1.3.16 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 80895 | 67444 | |||||||||||
| Ensembl | ENSG00000132323 | ENSMUSG00000026309 | |||||||||||
| UniProt | Q9H0C8 | Q8R0F6 | |||||||||||
| RefSeq (mRNA) | NM_030768 | NM_023343 | |||||||||||
| RefSeq (protein) | NP_110395 | NP_075832 | |||||||||||
| Location (UCSC) | Chr 2: 239.08 – 239.11 Mb | Chr 1: 91.38 – 91.4 Mb | |||||||||||
| PubMed search | |||||||||||||
Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.[1]
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.[1]
Interactions
ILKAP has been shown to interact with Integrin-linked kinase.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
- ↑ Leung-Hagesteijn, C; Mahendra A; Naruszewicz I; Hannigan G E (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". EMBO J. (England) 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. ISSN 0261-4189. PMC 125446. PMID 11331582.
Further reading
- Tong Y, Quirion R, Shen SH (1999). "Cloning and characterization of a novel mammalian PP2C isozyme". J. Biol. Chem. 273 (52): 35282–90. doi:10.1074/jbc.273.52.35282. PMID 9857069.
- Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". EMBO J. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kumar AS, Naruszewicz I, Wang P et al. (2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.