IL1RL2
| Interleukin 1 receptor-like 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IL1RL2 ; IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2 | ||||||||||||
| External IDs | OMIM: 604512 MGI: 1913107 HomoloGene: 2860 IUPHAR: 1736 GeneCards: IL1RL2 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8808 | 107527 | |||||||||||
| Ensembl | ENSG00000115598 | ENSMUSG00000070942 | |||||||||||
| UniProt | Q9HB29 | Q9ERS7 | |||||||||||
| RefSeq (mRNA) | NM_003854 | NM_133193 | |||||||||||
| RefSeq (protein) | NP_003845 | NP_573456 | |||||||||||
| Location (UCSC) | Chr 2: 102.8 – 102.86 Mb | Chr 1: 40.32 – 40.37 Mb | |||||||||||
| PubMed search | |||||||||||||
Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.[1][2][3][4]
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[4]
References
- ↑ Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.
- ↑ Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
- ↑ Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
- ↑ 4.0 4.1 "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".
Further reading
- McMahan CJ, Slack JL, Mosley B et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.". EMBO J. 10 (10): 2821–32. PMC 452992. PMID 1833184.
- Colotta F, Re F, Muzio M et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.". Science 261 (5120): 472–5. doi:10.1126/science.8332913. PMID 8332913.
- Torigoe K, Ushio S, Okura T et al. (1997). "Purification and characterization of the human interleukin-18 receptor.". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.
- Born TL, Smith DE, Garka KE et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ozkara C, Uzan M, Tanriverdi T et al. (2006). "Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis.". Seizure : the journal of the British Epilepsy Association 15 (5): 288–91. doi:10.1016/j.seizure.2006.02.016. PMID 16546408.