IL1RAPL2
| Interleukin 1 receptor accessory protein-like 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IL1RAPL2 ; IL-1R9; IL1R9; IL1RAPL-2; TIGIRR-1 | ||||||||||||
| External IDs | OMIM: 300277 MGI: 1913106 HomoloGene: 9681 GeneCards: IL1RAPL2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26280 | 60367 | |||||||||||
| Ensembl | ENSG00000189108 | ENSMUSG00000059203 | |||||||||||
| UniProt | Q9NP60 | Q9ERS6 | |||||||||||
| RefSeq (mRNA) | NM_017416 | NM_030688 | |||||||||||
| RefSeq (protein) | NP_059112 | NP_109613 | |||||||||||
| Location (UCSC) | Chr HG375_PATCH: 103.81 – 105.01 Mb | Chr X: 137.57 – 138.85 Mb | |||||||||||
| PubMed search | |||||||||||||
X-linked interleukin-1 receptor accessory protein-like 2 is a protein that in humans is encoded by the IL1RAPL2 gene.[1][2]
The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation.[2]
References
- ↑ Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG (May 2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur J Hum Genet 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID 10757639.
- ↑ 2.0 2.1 "Entrez Gene: IL1RAPL2 interleukin 1 receptor accessory protein-like 2".
Further reading
- Grundtman C, Salomonsson S, Dorph C et al. (2007). "Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies.". Arthritis Rheum. 56 (2): 674–87. doi:10.1002/art.22388. PMID 17265504.
- Libra M, Mangano K, Anzaldi M et al. (2006). "Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders.". Oncol. Rep. 15 (5): 1305–8. doi:10.3892/or.15.5.1305. PMID 16596202.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ferrante MI, Ghiani M, Bulfone A, Franco B (2001). "IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system.". Gene 275 (2): 217–21. doi:10.1016/S0378-1119(01)00659-X. PMID 11587848.
- Sana TR, Debets R, Timans JC et al. (2001). "Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3.". Genomics 69 (2): 252–62. doi:10.1006/geno.2000.6328. PMID 11031108.
- Born TL, Smith DE, Garka KE et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
- Nagaoka H, Ozawa K, Matsuda F et al. (1994). "Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16.". Genomics 22 (1): 189–97. doi:10.1006/geno.1994.1360. PMID 7959766.