IL12A

Interleukin 12A

PDB rendering based on 1f45.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1F45, 3HMX

Identifiers

Symbols

IL12A ; CLMF; IL-12A; NFSK; NKSF1; P35

External IDs

OMIM: 161560 MGI: 96539 HomoloGene: 681 GeneCards: IL12A Gene

Gene ontology
Molecular function	• cytokine activity • interleukin-12 receptor binding • protein binding • growth factor activity • interleukin-12 beta subunit binding • interleukin-27 binding • protein heterodimerization activity
Cellular component	• extracellular space • cytoplasm • interleukin-12 complex
Biological process	• positive regulation of T cell mediated cytotoxicity • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • immune response • cell cycle arrest • response to virus • response to UV-B • cell migration • response to lipopolysaccharide • negative regulation of interleukin-17 production • positive regulation of interferon-gamma production • positive regulation of natural killer cell activation • positive regulation of mononuclear cell proliferation • positive regulation of smooth muscle cell apoptotic process • positive regulation of T cell proliferation • positive regulation of tyrosine phosphorylation of Stat4 protein • defense response to protozoan • positive regulation of T cell differentiation • positive regulation of cell adhesion • positive regulation of natural killer cell mediated cytotoxicity • negative regulation of smooth muscle cell proliferation • positive regulation of lymphocyte proliferation • defense response to Gram-positive bacterium • positive regulation of NK T cell activation • extrinsic apoptotic signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
159.71 – 159.71 Mb

Chr 3:
68.69 – 68.7 Mb

PubMed search

Interleukin-12 subunit alpha is a protein that in humans is encoded by the IL12A gene.^[1]

Function

This gene encodes a subunit of the cytokine Interleukin 12 (IL-12) that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon gamma (INF-γ), and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.^[2]

References

↑ Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM (May 1991). "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells". J Immunol 146 (9): 3074–81. PMID 1673147.
↑ "Entrez Gene: IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)".

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Sieburth D, Jabs EW, Warrington JA, Li X, Lasota J, LaForgia S, Kelleher K, Huebner K, Wasmuth JJ, Wolf SF (1992). "Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.". Genomics 14 (1): 59–62. doi:10.1016/S0888-7543(05)80283-6. PMID 1358798.
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Ling P, Gately MK, Gubler U, Stern AS, Lin P, Hollfelder K, Su C, Pan YC, Hakimi J (1995). "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.". J. Immunol. 154 (1): 116–27. PMID 7527811.
Sharma V, Knobloch TJ, Benjamin D (1995). "Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines.". Biochem. Biophys. Res. Commun. 208 (2): 704–13. doi:10.1006/bbrc.1995.1395. PMID 7695626.
Radrizzani M, Accornero P, Amidei A, Aiello A, Delia D, Kurrle R, Colombo MP (1995). "IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.". Cell. Immunol. 161 (1): 14–21. doi:10.1006/cimm.1995.1003. PMID 7867080.
Fantuzzi L, Gessani S, Borghi P, Varano B, Conti L, Puddu P, Belardelli F (1996). "Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion.". J. Virol. 70 (6): 4121–4. PMC 190299. PMID 8648753.
Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN (1996). "Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells.". Nature 382 (6587): 171–4. doi:10.1038/382171a0. PMID 8700208.
Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G (1996). "Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.". J. Exp. Med. 184 (2): 747–52. doi:10.1084/jem.184.2.747. PMC 2192696. PMID 8760829.
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PDB gallery

1f45: HUMAN INTERLEUKIN-12

IL12A

Function

References

Further reading