IGHE

Immunoglobulin heavy constant epsilon

Available structures

Human UniProt search: PDBe, RCSB

List of PDB id codes
1F6A, 1FP5, 1G84, 1O0V, 2WQR, 2Y7Q, 3H9Y, 3H9Z, 3HA0, 4EZM, 4GRG, 4GT7

Identifiers

IGHE ; IgE

External IDs

OMIM: 147180 IUPHAR: 2741 GeneCards: IGHE Gene

Gene ontology
Molecular function	• antigen binding
Biological process	• immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

ENSG00000211891

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)

n/a

n/a

PubMed search

n/a

Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene.^[1]

References

↑ "Entrez Gene: IGHE immunoglobulin heavy constant epsilon".

Further reading

Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (1991). "The B-cell antigen receptor of the five immunoglobulin classes.". Nature 352 (6338): 777–81. doi:10.1038/352777a0. PMID 1881434.
Padlan EA, Davies DR (1987). "A model of the Fc of immunoglobulin E.". Mol. Immunol. 23 (10): 1063–75. doi:10.1016/0161-5890(86)90005-2. PMID 3796618.
Flanagan JG, Rabbitts TH (1984). "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.". EMBO J. 1 (5): 655–60. PMC 553102. PMID 6234164.
Max EE, Battey J, Ney R et al. (1982). "Duplication and deletion in the human immunoglobulin epsilon genes.". Cell 29 (2): 691–9. doi:10.1016/0092-8674(82)90185-4. PMID 6288268.
Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene.". DNA 1 (1): 11–8. PMID 6299662.
Seno M, Kurokawa T, Ono Y et al. (1983). "Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA.". Nucleic Acids Res. 11 (3): 719–26. doi:10.1093/nar/11.3.719. PMC 325748. PMID 6300763.
Ueda S, Nakai S, Nishida Y et al. (1984). "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns.". EMBO J. 1 (12): 1539–44. PMC 553248. PMID 6327276.
Hisajima H, Nishida Y, Nakai S et al. (1983). "Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin.". Proc. Natl. Acad. Sci. U.S.A. 80 (10): 2995–9. doi:10.1073/pnas.80.10.2995. PMC 393960. PMID 6407005.
Flanagan JG, Lefranc MP, Rabbitts TH (1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences.". Cell 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489.
Ellison J, Hood L (1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.". Proc. Natl. Acad. Sci. U.S.A. 79 (6): 1984–8. doi:10.1073/pnas.79.6.1984. PMC 346106. PMID 6804948.
Kenten JH, Molgaard HV, Houghton M et al. (1983). "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line.". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6661–5. doi:10.1073/pnas.79.21.6661. PMC 347188. PMID 6815656.
Valenta R, Natter S, Seiberler S et al. (1999). "Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients.". J. Invest. Dermatol. 111 (6): 1178–83. doi:10.1046/j.1523-1747.1998.00413.x. PMID 9856836.
Anderson GG, Leaves NI, Bhattacharyya S et al. (2002). "Positive association to IgE levels and a physical map of the 13q14 atopy locus.". Eur. J. Hum. Genet. 10 (4): 266–70. doi:10.1038/sj.ejhg.5200801. PMID 12032735.
Cocco RR, Järvinen KM, Sampson HA, Beyer K (2003). "Mutational analysis of major, sequential IgE-binding epitopes in alpha s1-casein, a major cow's milk allergen.". J. Allergy Clin. Immunol. 112 (2): 433–7. doi:10.1067/mai.2003.1617. PMID 12897753.
Hajoui O, Janani R, Tulic M et al. (2004). "Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production.". J. Allergy Clin. Immunol. 114 (3): 657–63. doi:10.1016/j.jaci.2004.05.034. PMID 15356573.
Takhar P, Smurthwaite L, Coker HA et al. (2005). "Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis.". J. Immunol. 174 (8): 5024–32. doi:10.4049/jimmunol.174.8.5024. PMID 15814733.
Batra J, Rajpoot R, Ahluwalia J et al. (2007). "A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels.". J. Med. Genet. 44 (6): 397–403. doi:10.1136/jmg.2006.046607. PMC 2740889. PMID 17220216.