IGF2BP3

Insulin-like growth factor 2 mRNA binding protein 3

PDB rendering based on 2e44.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2E44

Identifiers

Symbols

IGF2BP3 ; CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3

External IDs

OMIM: 608259 MGI: 1890359 HomoloGene: 4773 GeneCards: IGF2BP3 Gene

Gene ontology
Molecular function	• nucleotide binding • RNA binding • mRNA 3'-UTR binding • protein binding • poly(A) RNA binding • translation regulator activity • mRNA 5'-UTR binding
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• translation • anatomical structure morphogenesis • gene expression • negative regulation of translation • regulation of cytokine biosynthetic process • mRNA transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
23.35 – 23.51 Mb

Chr 6:
49.09 – 49.21 Mb

PubMed search

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.^[1]^[2]^[3]

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.^[3]

References

↑ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol 19 (2): 1262–70. PMC 116055. PMID 9891060.
↑ Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM (Jul 1997). "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein". Oncogene 14 (22): 2729–33. doi:10.1038/sj.onc.1201110. PMID 9178771.
↑ 3.0 3.1 "Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3".

Yaniv K, Yisraeli JK (2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.
Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260.
Mueller-Pillasch F, Pohl B, Wilda M et al. (2000). "Expression of the highly conserved RNA binding protein KOC in embryogenesis". Mech. Dev. 88 (1): 95–9. doi:10.1016/S0925-4773(99)00160-4. PMID 10525192.
Zhang JY, Chan EK, Peng XX et al. (2001). "Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies". Clin. Immunol. 100 (2): 149–56. doi:10.1006/clim.2001.5048. PMID 11465943.
Monk D, Bentley L, Beechey C et al. (2002). "Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome". J. Med. Genet. 39 (8): 575–81. doi:10.1136/jmg.39.8.575. PMC 1735212. PMID 12161597.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Nielsen J, Adolph SK, Rajpert-De Meyts E et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1". Biochem. J. 376 (Pt 2): 383–91. doi:10.1042/BJ20030943. PMC 1223771. PMID 12921532.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yantiss RK, Woda BA, Fanger GR et al. (2005). "KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas". Am. J. Surg. Pathol. 29 (2): 188–95. doi:10.1097/01.pas.0000149688.98333.54. PMID 15644775.
Liao B, Hu Y, Herrick DJ, Brewer G (2005). "The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells". J. Biol. Chem. 280 (18): 18517–24. doi:10.1074/jbc.M500270200. PMID 15753088.
Hammer NA, Hansen TO, Byskov AG et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer". Reproduction 130 (2): 203–12. doi:10.1530/rep.1.00664. PMID 16049158.
Feagins LA, Susnow N, Zhang HY et al. (2006). "Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (5): G871–5. doi:10.1152/ajpgi.00383.2005. PMID 16339295.
Vikesaa J, Hansen TV, Jønson L et al. (2006). "RNA-binding IMPs promote cell adhesion and invadopodia formation". EMBO J. 25 (7): 1456–68. doi:10.1038/sj.emboj.7601039. PMC 1440323. PMID 16541107.
Jiang Z, Chu PG, Woda BA et al. (2006). "Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study". Lancet Oncol. 7 (7): 556–64. doi:10.1016/S1470-2045(06)70732-X. PMID 16814207.
Li C, Rock KL, Woda BA et al. (2007). "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression". Mod. Pathol. 20 (2): 242–7. doi:10.1038/modpathol.3800735. PMID 17192788.

PDB gallery

2e44: Solution structure of RNA binding domain in Insulin-like growth factor 2 mRNA binding protein 3

IGF2BP3

References

Further reading