IFNB1

Interferon, beta 1, fibroblast

PDB rendering based on 1au1.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1AU1

Identifiers

Symbols

IFNB1 ; IFB; IFF; IFNB

External IDs

OMIM: 147640 MGI: 107657 HomoloGene: 1640 GeneCards: IFNB1 Gene

Gene ontology
Molecular function	• cytokine activity • type I interferon receptor binding
Cellular component	• extracellular region • extracellular space
Biological process	• adaptive immune response • T cell activation involved in immune response • B cell activation involved in immune response • natural killer cell activation involved in immune response • humoral immune response • cell surface receptor signaling pathway • blood coagulation • response to virus • cytokine-mediated signaling pathway • natural killer cell activation • B cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • cellular response to interferon-beta • B cell proliferation • defense response to bacterium • response to exogenous dsRNA • negative regulation of viral genome replication • innate immune response • positive regulation of innate immune response • regulation of MHC class I biosynthetic process • negative regulation of T cell differentiation • positive regulation of transcription from RNA polymerase II promoter • defense response to virus • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway • cellular response to exogenous dsRNA • negative regulation of T-helper 2 cell cytokine production • positive regulation of apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
21.08 – 21.08 Mb

Chr 4:
88.52 – 88.52 Mb

PubMed search

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.^[1] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.^[2] Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

References

Biron CA, Nguyen KB, Pien GC (2002). "Innate immune responses to LCMV infections: natural killer cells and cytokines.". Curr. Top. Microbiol. Immunol. 263: 7–27. doi:10.1007/978-3-642-56055-2_2. PMID 11987821.
Conti L, Fantuzzi L, Del Cornò M et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
Bekisz J, Schmeisser H, Hernandez J et al. (2005). "Human interferons alpha, beta and omega". Growth Factors 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727.
Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini reviews in medicinal chemistry 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.
May LT, Sehgal PB (1985). "On the relationship between human interferon alpha 1 and beta 1 genes". J. Interferon Res. 5 (3): 521–6. PMID 2414376.
Francois DT, Katona IM, June CH et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. doi:10.1016/0090-1229(88)90023-2. PMID 3135963.
Conradt HS, Egge H, Peter-Katalinic J et al. (1987). "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line". J. Biol. Chem. 262 (30): 14600–5. PMID 3667593.
Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5.215. PMID 3872918.
Derynck R, Content J, DeClercq E et al. (1980). "Isolation and structure of a human fibroblast interferon gene". Nature 285 (5766): 542–7. doi:10.1038/285542a0. PMID 6157094.
Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene 10 (1): 11–5. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.
Houghton M, Easton MA, Stewart AG et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. doi:10.1093/nar/8.13.2885. PMC 324132. PMID 6159580.
Goeddel DV, Shepard HM, Yelverton E et al. (1981). "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. doi:10.1093/nar/8.18.4057. PMC 324219. PMID 6159584.
Houghton M, Stewart AG, Doel SM et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. doi:10.1093/nar/8.9.1913. PMC 324047. PMID 6159597.
Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature 289 (5798): 606–7. doi:10.1038/289606a0. PMID 6162107.
Lawn RM, Adelman J, Franke AE et al. (1981). "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. doi:10.1093/nar/9.5.1045. PMC 326735. PMID 6164984.
Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature 294 (5841): 563–5. doi:10.1038/294563a0. PMID 6171735.
Content J, De Wit L, Pierard D et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. doi:10.1073/pnas.79.9.2768. PMC 346287. PMID 6178110.
Fiers W, Remaut E, Devos R et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 299 (1094): 29–38. doi:10.1098/rstb.1982.0103. PMID 6183692.

PDB gallery

1au1: HUMAN INTERFERON-BETA CRYSTAL STRUCTURE

Cell signaling: cytokines

By family

Chemokine

CCL	CCL1 CCL2/MCP-1 CCL3/MIP-1α CCL4/MIP-1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18/PARC/DC-CK1/AMAC-1/MIP-4 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28

CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17

CX3CL	CX3CL1

XCL	XCL1 XCL2

TNF

Interleukin

Type I
(grouped by
receptor
subunit)

γ-chain	IL2/IL15 IL4/IL13 IL7 IL9 IL21

β-chain	IL3 IL5 GM-CSF

IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non IL OSM LIF CNTF CTF1

IL12 family/IL12RB1	IL12 IL23 IL27 IL35

Other	IL14 IL16 IL32 IL34

Type II

IL10 family

IL10/IL22
IL19
IL20
IL24
IL26
Interferon type III
- IL28/IFNL2+3
- IL29/IFNL1

Interferon

I	IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1

II	IFNG

Ig superfamily

IL17 family

IL17/IL25 (IL17A)

Other

Hematopoietic
- KITLG
- Colony-stimulating factor
SPP1
MIF

By function/
cell

proinflammatory cytokine
- IL1
- TNFA

Monokine
Lymphokine
- T_h1
  - IFNG
  - TNFB
- T_h2
  - IL4
  - IL5
  - IL6
  - IL10
  - IL13

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

IFNB1

References

Further reading