Hycanthone
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Systematic (IUPAC) name | |
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1-(2-Diethylaminoethylamino)-4-(hydroxymethyl)-9-thioxanthenone | |
Clinical data | |
Identifiers | |
3105-97-3 ![]() | |
None | |
PubChem | CID 3634 |
ChemSpider |
3508 ![]() |
UNII |
2BXX5EVN2A ![]() |
KEGG |
D00541 ![]() |
ChEBI |
CHEBI:52768 ![]() |
ChEMBL |
CHEMBL22077 ![]() |
Chemical data | |
Formula | C20H24N2O2S |
356.48 g/mol | |
SMILES
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Hycanthone is the schistosomicide approved by the FDA in 1975. It is a metabolite of lucanthone. Hycanthone interferes with parasite nerve function, resulting in paralysis and death. This agent also intercalates into DNA and inhibits RNA synthesis in vitro and shows potential antineoplastic activity.[1]
Anti-schistosomal activity
Hycanthone is shown to be an effective inhibitor of acetylcholinesterase (AChE) from Schistosoma mansoni, but is less potential against AChE from mammalian origin. This might come from differences in the configuration of active center between schistosome and mammalian AChE enzymes..[2]
Hycanthone is shown to intercalates into DNA and inhibit RNA synthesis in vitro. A growing body of evidence has shown that hycathone has an antineoplastic activity.
Clinical trials
- Phase II Study of Chemotherapy with Hycanthone for Advanced Colorectal Carcinoma (Completed)
- Phase II Chemotherapy with Hycanthone Mesylate and Flagyl for Advanced Malignant Lymphomas (Completed)[3]
Physical properties
Physical state | Solid |
Solubility | Soluble in ethanol, methanol, DMSO, and water |
Absorption maximum | 233, 258, 329, 438 nm |
Melting point | 173-176 °C |
logP | 3.74 |
References
- ↑ NCI Cancer Dictionary
- ↑ Hillman, GR; Senft, AW (1975). "Anticholinergic properties of the antischistosomal drug hycanthone". The American journal of tropical medicine and hygiene 24 (5): 827–834. PMID 1190369.
- ↑ http://www.cancer.gov/clinicaltrials/search/results?protocolsearchid=10235377