Homatropine

Homatropine
Systematic (IUPAC) name
(N-methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a601006
  • rx only not FDA approved only sold in UK
Identifiers
87-00-3 
A02BX03 S01FA05
PubChem CID 6321423
DrugBank DB00725 
ChemSpider 16498795 Yes
UNII 8QS6WCL55Z Yes
ChEMBL CHEMBL1233442 
Chemical data
Formula C16H21NO3
356.26 g/mol
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Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). For Homatropine methylbromide see Methylhomatropine, this is a different medication. Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide salt.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

Side effects

Complications

References