Hexadimethrine bromide
 | |
| Names | |
|---|---|
| IUPAC name
1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide | |
| Other names
Polybrene | |
| Identifiers | |
28728-55-4  | |
| ChemSpider | |
| Properties | |
| (C13H30Br2N2)n, linear form | |
| Molar mass | variable |
| Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| Infobox references | |
Hexadimethrine bromide (Polybrene) is a cationic polymer used to increase the efficiency of infection of certain cells with a retrovirus in cell culture. Polybrene acts by neutralizing the charge repulsion between virions and sialic acid on the cell surface.[1] It has other uses, including a role in protein sequencing.
Historically, hexadimethrine bromide was sometimes used to reverse heparin anticoagulation during open-heart surgery. Its use has been supplanted by protamine sulfate.
The IUPAC name for hexadimethrine bromide is 1,5-dimethyl-1,5-diazaundecamethylene polymethobromide.
References
- ↑ Howard E. Davis, Matthew Rosinski , Jeffrey R. Morgan and Martin L. Yarmush et al. (2004). "Charged Polymers Modulate Retrovirus Transduction via Membrane Charge Neutralization and Virus Aggregation.". Biophysical Journal 86 (2): 1234–42. doi:10.1016/S0006-3495(04)74197-1. PMC 1303915. PMID 14747357.