Hematidrosis

blood sweat

Hematidrosis (also called hematohidrosis or hemidrosis or blood sweat) is a very rare condition in which a human sweats blood.[1]

Signs and symptoms

Blood usually oozes from the forehead, nails, umbilicus, and other skin surfaces. In addition, oozing from mucocutaneous surfaces causing nosebleeds, blood stained tears, and vicarious menstruation are common.[2] The episodes may be proceeded by intense headache and abdominal pain and are usually self-limiting. In some conditions, the secreted fluid is more dilute and appears to be blood-tinged, while others may have darker bright red secretions resembling blood.[3]

Investigations

Investigation such as platelets count, platelet aggregation test, coagulation profile and skin biopsy reveal no abnormalities and direct light microscopy of fluid demonstrates presence of normal red blood cells. Investigations also failed to show any vasculitis or skin appendages (i.e. sweat glands, sebaceous glands and hair follicles) abnormalities.[3][4]

Treatment

The condition is very rare but there are reports in medical literature of successful treatment with beta blockers (propranolol 10 mg)[5][6] with significant reduction in the frequency of spontaneous blood oozing. The successful use of beta blockers supports the theory that the condition is induced by stress and anxiety yet this etiology is not established yet as the high prevalence of stress and anxiety in the modern era did not change the incidence of this extremely rare disease, suggesting that other co-abnormality also play a key role in this disease.[4] Atropine sulfate transdermal patches have also been used successfully.[3]

See also

References

  1. ↑ Tshifularo, M. (2014). "Blood otorrhea: blood stained sweaty ear discharges: hematohidrosis; four case series (2001-2013).". American Journal of Otolarynology 35 (2): 271–3. doi:10.1016/j.amjoto.2013.09.006. PMID 24315735.
  2. ↑ Holoubek, J. E.; Holoubek, A. B. (1996). "Blood, sweat and fear. "A classification of hematidrosis"". Journal of medicine 27 (3–4): 115–33. PMID 8982961.
  3. ↑ 3.0 3.1 3.2 Biswas, S.; Surana, T.; De, A.; Nag, F. (2013). "A curious case of sweating blood". Indian Journal of Dermatology 58 (6): 478–80. doi:10.4103/0019-5154.119964. PMC 3827523. PMID 24249903.
  4. ↑ 4.0 4.1 Mora, E; Lucas, J (2013). "Hematidrosis: Blood sweat". Blood 121 (9): 1493. doi:10.1182/blood-2012-09-450031. PMID 23570065.
  5. ↑ Wang, Z.; Yu, Z.; Su, J.; Cao, L.; Zhao, X.; Bai, X.; Zhan, S.; Wu, T.; Jin, L.; Zhou, P.; Ruan, C. (2010). "A Case of Hematidrosis Successfully Treated with Propranolol". American Journal of Clinical Dermatology 11 (6): 440–3. doi:10.2165/11531690-000000000-00000. PMID 20666570.
  6. ↑ Khalid, S. R.; Maqbool, S; Raza, N; Mukhtar, T; Ikram, A; Qureshi, S (2013). "Ghost spell or hematohidrosis". Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 23 (4): 293–4. PMID 23552544.