Harold Frost

Harold M. Frost (1921 – 19 June 2004) was an US-American orthopedist and surgeon considered to be one of the most important researchers and theorists in the field of bone biology and bone medicine of his time.^[1][2][3] He published nearly 500 peer-reviewed scientific and clinical articles and 16 Books and is according to the Science Citation Index one of the most cited investigators in skeletal research.^[1]

His main academic inputs included:^[1]

• Development of Bone Histomorphometry for description of cellular based bone formation and Bone resorption processes
• the eleventh rip Biopsy used for diagnosis of metabolic Bone diseases
• Research on the multi-cellular unit as a key to bone metabolism
• the experimental proof that Estrogen reduces bone formation
• the histological proof of micro-damages in human bone biopsies
• the basic model of the adaptation of the Growth plate to mechanical stress
• the Utah-Paradigm of Bone physiology (Mechanostat-Theorem), an enhancement of Wolff's law stating that Bone adapts to mechanical stress and that hence there is a close link between muscle and bone

Books by Harold M. Frost

• Bone remodelling dynamics, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1963
• The laws of bone structure, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1964
• Mathematical Elements of Lamellar Bone Remodelling, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1964
• Bone biodynamics, Henry Ford Hospital international symposium, [14], Little, Brown (Boston) 1964
• The bone dynamics in osteoporosis and osteomalacia, The Henry Ford Hospital surgical monographs, Thomas (Springfield, Ill.), 1966
• An introduction to biomechanics, Surgical monographs, Thomas (Springfield, Ill.), 1967, 0398028249
• Orthopaedic surgery in spasticity (Orthopaedic lectures Vol. 1), Thomas (Springfield, Ill.), 1972
• The physiology of cartilaginous, fibrous, and bony tissue (Orthopaedic lectures Vol. 2), Thomas (Springfield, Ill.), 1972, ISBN 0-398-02562-2
• Bone remodeling and its relationship to metabolic bone diseases (Orthopaedic lectures Vol. 3), Thomas (Springfield, Ill.), 1973, ISBN 0-398-02588-6
• Bone modeling and skeletal modeling errors (Orthopaedic lectures Vol. 4), Thomas (Springfield, Ill.), 1973, ISBN 0-398-02667-X
• Orthopaedic Biomechanics (Orthopaedic Lectures Vol. 5), Thomas (Springfield, Ill.), 1973, ISBN 0-398-02824-9
• Symposium on the Osteoporoses Part 1: Physioplogy, Pathophysiology, and Diagnosis, Saunders (Philadelphia), 1981
• Symposium on the Osteoporoses Part 2: Therapy and Prevention, Saunders (Philadelphia), 1981
• Intermediary organization of the skeleton, CRC Press (Boca Raton, Fla), 1986, ISBN 0-8493-5948-1
• Bone in clinical orthopedics - Chapter 14: Determinants of bone strength and mass: a summary and clinical implications by Geoff Sumner-Smith, Georg Thieme Verlag, 2002, ISBN 0-86577-829-9,
• The Utah Paradigm of Skeletal Physiology Vol. 1, ISMNI
• The Utah Paradigm of Skeletal Physiology Vol. 2, ISMNI

References

External links

• Tribute to Harold Frost in Journal of Musculoskeletal Neuronal Interactions, 4(4), 2004, 348-356
• Harold M. Frost, M.D., D.Sc. (hon) – One man’s association in Journal of Musculoskeletal Neuronal Interactions, 6(2), 2006
• Harold M Frost William F. Neuman Awardee 2001 in Journal of Musculoskeletal Neuronal Interactions, 2(2), 2001, 117-119
• ASBMR Harold M. Frost Young Investigator Award
• ISMNI - International Society of Musculoskeletal and Neuronal Interactions
• Sun Valley Workshops - IBMS Annual Sun Valley Workshops