Haplogroup O-M175

Haplogroup O-M175

Possible time of origin	28,000-41,000 years BP (Scheinfeldt 2006)
Possible place of origin	Southeast or East Asia
Ancestor	NO
Descendants	O-MSY2.2, O-M268, O-M122
Defining mutations	M175, P186, P191, P196

In molecular evolution, a haplogroup (from the Greek: ἁπλούς, haploûs, "onefold, single, simple") is a group of similar haplotypes that share a common ancestor having the same single nucleotide polymorphism (SNP) mutation in all haplotypes. Haplogroup O-M175 is a Y-chromosome DNA haplogroup of Southeast Asian and East Asian lineage. It descends from Haplogroup NO.

Origins

Haplogroup O-M175 is a descendant haplogroup of Haplogroup NO-M214, and first appeared according to different theories, either in Southeast Asia (see Rootsi 2006, TMC ?, Shi 2005, and Bradshaw ?) or East Asia (see ISOGG 2012) between 28,000 and 41,000 years before present according to Scheinfeldt 2006 or between 23,000 and 32,000 years before present according to Yan et al. 2013.^[1]

Haplogroup O-M175 is one of NO-M214's two branches. The other is Haplogroup N, which is common throughout North Eurasia.

Distribution

This haplogroup appears in 80-90% of most of populations in East Asia and Southeast Asia, and it is almost exclusive to that region: M175 is almost nonexistent in Western Siberia, Western Asia, Europe, Africa, or the Americas, where its presence may be the result of recent migrations. Notably, certain subclades of Haplogroup O-M175 do achieve significant frequencies among some populations of South Asia, Central Asia, and Oceania.

Among the subbranches of Haplogroup O-M175 are O-MSY2.2, O-M268, and O-M122.

Paragroup O-M175

Paragroup O-M175 lineages, which belong to Haplogroup O-M175 but do not display any of the later mutations that define the major subclades O-MSY2.2, O-M268, and O-M122, can be detected at a low frequency among some modern populations of Central Asia and East Asia. A broad survey of Y-chromosome variation among populations of central Eurasia found haplogroup O-M175(xM119,M95,M122) in a significant minority of Koreans (Wells 2001). However, nearly all of these Korean O-M175(xM119,M95,M122) Y-chromosomes may belong to Haplogroup O-M176,^{[Footnote 1]} and later studies do not support the finding of Paragroup O-M175(Xue 2005, Kim 2011). O-M175(xM119,M95,M122) Y-chromosomes that have been found among these populations might therefore belong to Haplogroup O-MSY2.2*(xM119), Haplogroup O-M268*(xM95,M176), or Haplogroup O-M176.

O-F75

O1-MSY2.2 and O2-M268 share a common ancestor, O-F75, approximately 23,400 [95% CI 21,600 to 25,300] YBP.^[1]. O-F75, in turn, coalesces to a common ancestor with O3-M122 approximately 24,700 [95% CI 23,000 to 26,500] YBP.^[1] Thus, O-F75 existed as a single haplogroup parallel to O3-M122 for a duration of approximately 1,300 years (or anywhere from 0 to 4,900 years considering the 95% CIs and assuming that the phylogeny is correct) before breaking up into its two extant descendant haplogroups, O1-MSY2.2 and O2-M268.

O-MSY2.2

O-M119: Found frequently in Austronesian-speaking people, with a moderate distribution in southern Chinese ethnic groups and Tai–Kadai peoples.

O-M268

O-PK4
- O-M95
  - O-M95(xM88): Found frequently among Austroasiatic- and Tai-speaking peoples, Malays, western Indonesians, and Malagasy, with a moderate distribution throughout South Asia, (Firasat 2006 and Fornarino 2009) Southeast Asia, East Asia, and Central Asia.
  - O-M88: Found frequently among Hani, She people, Tai peoples, Cambodians, and Vietnamese, with a moderate distribution among Qiang, Yi, Hlai, Miao, Yao, Taiwanese aborigines, and Han Chinese.
O-M176
- O-M176(x47z): Found frequently among Koreans, with a moderate distribution among Buryats, Daurs, Evenks, Hezhe, Indonesians, Japanese, Manchus, Micronesians, Ryukyuans, Sibe, Thais, Udegeys, and Vietnamese.
- O-47z: Found frequently among Japanese and Ryukyuans, with a moderate distribution among Indonesians, Koreans, Manchus, Thais, and Vietnamese.

O-M122

Found frequently among populations of East Asia, Southeast Asia, and culturally Austronesian regions of Oceania, with a moderate distribution in Central Asia (Shi 2005).

O-M134: Found frequently among Sino-Tibetan peoples, with a moderate distribution throughout East Asia and Southeast Asia.
O-M7: Found frequently among human remains associated with the Neolithic Daxi culture^[2] and modern Hmong–Mien, Katuic, and Bahnaric peoples,^[3] with a moderate distribution among Han Chinese (Xue 2006), Buyei (Xue 2006), Bai (Wen 2004), Mosuo (Wen 2004), Tibetans (Wen 2004), Qiang (Xue 2006), Oroqen (Xue 2006), Tujia (Su 2000), Thai (Su 2000), Orang Asli (Su 2000), western Indonesians (Su 2000 and Kayser 2008), Malaysians (Kayser 2008), Vietnamese (Kayser 2008), and Atayal (Su 2000).

Languages families and genes

The following is a phylogenetic tree of language families and their corresponding SNP markers, or haplogroups, sourced mainly from Edmondson 2007 and Shi 2005. This has been called the "Father Tongue Hypothesis" by George van Driem (vanDriem 2011). It does not appear to account for O-M176, which is found among Japanese, Korean, and Manchurian males.

"Proto- Asiatic" (O-M175)

Northern Asiatic (O-M122)

Sino-Tibetan (O-M134)

	Sinitic (O-M117)

	Tibeto-Burman

Hmong–Mien (O-M7)

	Hmong (Miao)

	She (Ratliff 1998)

Mien (Yao)

Southern Asiatic (Austric)

Austroasiatic (O-M95)

	Munda

	Mon–Khmer

Austro-Tai (O-M119)

Austronesian

	Formosan

	Malayo-Polynesian

Tai–Kadai

Kadai ^{[Footnote 2]}

Kam–Tai

	Kam–Sui

	Tai

Phylogenetics

Phylogenetic history

Main article: Conversion table for Y chromosome haplogroups

Prior to 2002, there were in academic literature at least seven naming systems for the Y-Chromosome Phylogenetic tree. This led to considerable confusion. In 2002, the major research groups came together and formed the Y-Chromosome Consortium (YCC). They published a joint paper that created a single new tree that all agreed to use. Later, a group of citizen scientists with an interest in population genetics and genetic genealogy formed a working group to create an amateur tree aiming at being above all timely. The table below brings together all of these works at the point of the landmark 2002 YCC Tree. This allows a researcher reviewing older published literature to quickly move between nomenclatures.

YCC 2002/2008 (Shorthand)	(α)	(β)	(γ)	(δ)	(ε)	(ζ)	(η)	YCC 2002 (Longhand)	YCC 2005 (Longhand)	YCC 2008 (Longhand)	YCC 2010r (Longhand)	ISOGG 2006	ISOGG 2007	ISOGG 2008	ISOGG 2009	ISOGG 2010	ISOGG 2011	ISOGG 2012
O-M175	26	VII	1U	28	Eu16	H9	I	O*	O	O	O	O	O	O	O	O	O	O
O-M119	26	VII	1U	32	Eu16	H9	H	O1*	O1a	O1a	O1a	O1a	O1a	O1a	O1a	O1a	O1a	O1a
O-M101	26	VII	1U	32	Eu16	H9	H	O1a	O1a1	O1a1a	O1a1a	O1a1	O1a1	O1a1a	O1a1a	O1a1a	O1a1a	O1a1a
O-M50	26	VII	1U	32	Eu16	H10	H	O1b	O1a2	O1a2	O1a2	O1a2	O1a2	O1a2	O1a2	O1a2	O1a2	O1a2
O-P31	26	VII	1U	33	Eu16	H5	I	O2*	O2	O2	O2	O2	O2	O2	O2	O2	O2	O2
O-M95	26	VII	1U	34	Eu16	H11	G	O2a*	O2a	O2a	O2a	O2a	O2a	O2a	O2a	O2a	O2a1	O2a1
O-M88	26	VII	1U	34	Eu16	H12	G	O2a1	O2a1	O2a1	O2a1	O2a1	O2a1	O2a1	O2a1	O2a1	O2a1a	O2a1a
O-SRY465	20	VII	1U	35	Eu16	H5	I	O2b*	O2b	O2b	O2b	O2b	O2b	O2b	O2b	O2b	O2b	O2b
O-47z	5	VII	1U	26	Eu16	H5	I	O2b1	O2b1a	O2b1	O2b1	O2b1a	O2b1a	O2b1	O2b1	O2b1	O2b1	O2b1
O-M122	26	VII	1U	29	Eu16	H6	L	O3*	O3	O3	O3	O3	O3	O3	O3	O3	O3	O3
O-M121	26	VII	1U	29	Eu16	H6	L	O3a	O3a	O3a1	O3a1	O3a1	O3a1	O3a1	O3a1	O3a1	O3a1a	O3a1a
O-M164	26	VII	1U	29	Eu16	H6	L	O3b	O3b	O3a2	O3a2	O3a2	O3a2	O3a2	O3a2	O3a2	O3a1b	O3a1b
O-M159	13	VII	1U	31	Eu16	H6	L	O3c	O3c	O3a3a	O3a3a	O3a3	O3a3	O3a3a	O3a3a	O3a3a	O3a3a	O3a3a
O-M7	26	VII	1U	29	Eu16	H7	L	O3d*	O3c	O3a3b	O3a3b	O3a4	O3a4	O3a3b	O3a3b	O3a3b	O3a2b	O3a2b
O-M113	26	VII	1U	29	Eu16	H7	L	O3d1	O3c1	O3a3b1	O3a3b1	-	O3a4a	O3a3b1	O3a3b1	O3a3b1	O3a2b1	O3a2b1
O-M134	26	VII	1U	30	Eu16	H8	L	O3e*	O3d	O3a3c	O3a3c	O3a5	O3a5	O3a3c	O3a3c	O3a3c	O3a2c1	O3a2c1
O-M117	26	VII	1U	30	Eu16	H8	L	O3e1*	O3d1	O3a3c1	O3a3c1	O3a5a	O3a5a	O3a3c1	O3a3c1	O3a3c1	O3a2c1a	O3a2c1a
O-M162	26	VII	1U	30	Eu16	H8	L	O3e1a	O3d1a	O3a3c1a	O3a3c1a	O3a5a1	O3a5a1	O3a3c1a	O3a3c1a	O3a3c1a	O3a2c1a1	O3a2c1a1

Original Research Publications

The following research teams per their publications were represented in the creation of the YCC Tree.

α Jobling and Tyler-Smith 2000 and Kaladjieva 2001
β Underhill 2000
γ Hammer 2001
δ Karafet 2001
ε Semino 2000
ζ Su 1999
η Capelli 2001

Phylogenetic trees

This phylogenetic tree of haplogroup O subclades is based on the YCC 2008 tree (Karafet 2008) and subsequent published research.

O (M175, P186, P191, P196)
- O-MSY2.2 (MSY2.2)
  - O-M119 (M119)
    - O-P203.2 (M307.2/P203.2)
    - O-M50 (M50, M103, M110)
- O-P31 (P31, M268)
  - O-F1462
    - O-PK4
      - O-M95 (M95)
        O-M88 (M88, M111)
  - O-M176 (M176/SRY465, P49, 022454)
    - O-47z (47z)
- O-M122 (M122, P198)
  - O-P93 (M324, P93, P197, P198, P199, P200)
    - O-M121 (M121, P27.2)
    - O-M164 (M164)
    - O-P201 (P201/021354)
    - O-002611 (002611)
    - O-M300 (M300)
    - O-M333 (M333)

Evolutionary tree of human Y-chromosome DNA (Y-DNA) haplogroups
ISOGG Y-DNA Haplogroup Tree 2015(1 February 2015)PDF^{[n 1]}
	MRC Y-ancestor
	A00	A0'1'2'3'4
	A0	A1'2'3'4
	A1	A2'3'4
	A2'3	A4=BCDEF
	A2	A3	B	CDEF
	DE	CF
	D	E	C	F
	GHIJKLT
	G	HIJKLT
	H	IJKLT
	IJ	KLT (K)
	I	J	LT(K1)	K (K2)
	L	T	MPS (K2b)	X (K2a)
	MS	P	NO
	M	S	QR		N	O
	Q	R
Y-DNA by populations Famous Y-DNA haplotypes
↑ van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809.

References

Footnotes

↑ O-M175(xM119,M95,M122) is sometimes incorrectly called "O*".
↑ The outlier Kadai branch is called "Kra" by Thai linguist Weera Ostapirat and "Geyang" by Chinese linguists.

Works cited

Journals

Edmondson, Jerold A. (2007). Jimmy G. Harris, Somsonge Burusphat and James E. Harris, ed. "The power of language over the past: Tai settlement and Tai linguistics in southern China and northern Vietnam" (PDF). Studies in Southeast Asian languages and linguistics (Bangkok, Thailand: Ek Phim Thai Co. Ltd.).
van Driem, George (2011). "Rice and the Austroasiatic and Hmong-Mien Homelands" (PDF). In N. J. Enfield, ed. Dynamics of Human Diversity, 361-390 (Canberra: Pacific Linguistics).
Firasat, Sadaf; Khaliq, Shagufta; Mohyuddin, Aisha; Papaioannou, Myrto; Tyler-Smith, Chris; Underhill, Peter A; Ayub, Qasim (2006). "Y-chromosomal evidence for a limited Greek contribution to the Pathan population of Pakistan". European Journal of Human Genetics 15 (1): 121–6. doi:10.1038/sj.ejhg.5201726. PMC 2588664. PMID 17047675.
Fornarino, Simona; Pala, Maria; Battaglia, Vincenza; Maranta, Ramona; Achilli, Alessandro; Modiano, Guido; Torroni, Antonio; Semino, Ornella; Santachiara-Benerecetti, Silvana A (2009). "Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation". BMC Evolutionary Biology 9 (1): 154. doi:10.1186/1471-2148-9-154. PMC 2720951. PMID 19573232.
Karafet, T. M.; Mendez, F. L.; Meilerman, M. B.; Underhill, P. A.; Zegura, S. L.; Hammer, M. F. (2008). "New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree". Genome Research 18 (5): 830–8. doi:10.1101/gr.7172008. PMC 2336805. PMID 18385274.
Kayser, M.; Choi, Y.; Van Oven, M.; Mona, S.; Brauer, S.; Trent, R. J.; Suarkia, D.; Schiefenhovel, W.; Stoneking, M. (2008). "The Impact of the Austronesian Expansion: Evidence from mtDNA and Y Chromosome Diversity in the Admiralty Islands of Melanesia". Molecular Biology and Evolution 25 (7): 1362–74. doi:10.1093/molbev/msn078. PMID 18390477.
Kim, SH; Kim, Ki-Cheol; Shin, Dong-Jik; Jin, Han-Jun; Kwak, Kyoung-Don; Han, Myun-Soo; Song, Joon-Myong; Kim, Won; Kim, Wook (2011). "High frequencies of Y-chromosome haplogroup O2b-SRY465 lineages in Korea: a genetic perspective on the peopling of Korea". Investigative Genetics 2 (10): 10. doi:10.1186/2041-2223-2-10. PMC 3087676. PMID 21463511.
Ratliff, Martha (1998). "Ho Ne (She) is Hmongic: One final argument" (PDF). Linguistics of the Tibeto-Burman Area 21.2:97-109.
Rootsi, Siiri; Zhivotovsky, Lev A; Baldovič, Marian; Kayser, Manfred; Kutuev, Ildus A; Khusainova, Rita; Bermisheva, Marina A; Gubina, Marina et al. (2006). "A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe". European Journal of Human Genetics 15 (2): 204–11. doi:10.1038/sj.ejhg.5201748. PMID 17149388.
Scheinfeldt, L.; Friedlaender, F; Friedlaender, J; Latham, K; Koki, G; Karafet, T; Hammer, M; Lorenz, J (2006). "Unexpected NRY Chromosome Variation in Northern Island Melanesia". Molecular Biology and Evolution 23 (8): 1628–41. doi:10.1093/molbev/msl028. PMID 16754639.
Shi, Hong; Dong, Yong-li; Wen, Bo; Xiao, Chun-Jie; Underhill, Peter A.; Shen, Pei-Dong; Chakraborty, Ranajit; Jin, Li; Su, Bing (2005). "Y-Chromosome Evidence of Southern Origin of the East Asian–Specific Haplogroup O3-M122". The American Journal of Human Genetics 77 (3): 408–19. doi:10.1086/444436. PMC 1226206. PMID 16080116.
Su, B.; Jin, Li; Underhill, Peter; Martinson, Jeremy; Saha, Nilmani; McGarvey, Stephen T.; Shriver, Mark D.; Chu, Jiayou et al. (2000). "Polynesian origins: Insights from the Y chromosome". Proceedings of the National Academy of Sciences 97 (15): 8225–8228. Bibcode:2000PNAS...97.8225S. doi:10.1073/pnas.97.15.8225.
Wells, R. Spencer; Yuldasheva, N.; Ruzibakiev, R.; Underhill, P. A.; Evseeva, I.; Blue-Smith, J.; Jin, L.; Su, B. et al. (August 2001). "The Eurasian heartland: a continental perspective on Y-chromosome diversity". Proceedings of the National Academy of Sciences 98 (18): 10244–9. Bibcode:2001PNAS...9810244W. doi:10.1073/pnas.171305098. PMC 56946. PMID 11526236.
Wen, W; Hong, S; Ling, R; Huifeng, X; Kaiyuan, L; Wenyi, Z; Bing, S; Shiheng, S et al. (2004). "The origin of Mosuo people as revealed by mtDNA and Y chromosome variation". Science China Life Sciences 47 (1): 1–10. doi:10.1360/02yc0207. PMID 15382670.
Xue, Y.; Zerjal, T; Bao, W; Zhu, S; Shu, Q; Xu, J; Du, R; Fu, S et al. (2005). "Male Demography in East Asia: A North–South Contrast in Human Population Expansion Times". Genetics 172 (4): 2431–9. doi:10.1534/genetics.105.054270. PMC 1456369. PMID 16489223.

Websites

Bradshaw Foundation. "Journey of Man - The Peopling of the World".
ISOGG (2012). "Y-DNA Haplogroup O and its Subclades - 2012".
TMC (1998). "Genetic Findings Support 'Out of Africa' Theory".

References

↑ 1.0 1.1 1.2 Shi Yan, Chuan-Chao Wang, Hong-Xiang Zheng et al. (2013), "Y Chromosomes of 40% Chinese Are Descendants of Three Neolithic Super-grandfathers." E-print at arXiv:1310.3897 [q-bio.PE].
↑ Li, Hui; Huang, Ying; Mustavich, Laura F.; Zhang, Fan; Tan, Jing-Ze; Ling-; Wang, E; Qian, Ji; Gao, Meng-He; Jin, Li (2007). "Y chromosomes of prehistoric people along the Yangtze River". Human Genetics 122 (3-4): 383–388. doi:10.1007/s00439-007-0407-2. PMID 17657509.
↑ Cai, X; Qin, Z; Wen, B; Xu, S; Wang, Y et al. (2011). "Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes". PLoS ONE 6 (8): e24282. doi:10.1371/journal.pone.0024282. PMC 3164178. PMID 21904623.

External links

Spread of Haplogroup O, from The Genographic Project, National Geographic
Y-DNA Phylogenetic Tree of Haplogroup O (DNAHaplogroups.org)
Migration patterns of early Humans and the full size map
China DNA at Family Tree DNA

Haplogroup O-M175

Origins

Distribution

Paragroup O-M175

O-F75

O-MSY2.2

O-M268

O-M122

Languages families and genes

Phylogenetics

Phylogenetic history

Original Research Publications

Phylogenetic trees

See also

Genetics

Y-DNA O subclades

Y-DNA backbone tree

References

Footnotes

Works cited

References

External links