Haloprogin

"Polik" redirects here. For other uses, see Polik (disambiguation).
Haloprogin
Systematic (IUPAC) name
1,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
Clinical data
  • Not available in U.S.
Topical
Identifiers
777-11-7 Yes
D01AE11
PubChem CID 3561
DrugBank DB00793 Yes
ChemSpider 3440 Yes
UNII AIU7053OWL Yes
KEGG D00339 Yes
ChEMBL CHEMBL1289 Yes
Chemical data
Formula C9H4Cl3IO
361.39 g/mol
Physical data
Melting point 113.5 °C (236.3 °F)
insoluble mg/mL (20 °C)
 Yes (what is this?)  (verify)

Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections. It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik.

Action

Haloprogin was previously used in 1% topical creams as an antifungal agent. It was marketed over the counter primarily to treat tinea infections of the skin. The mechanism of action is unknown.[1]

Haloprogin had a high incidence of side effects including: irritation, burning, vesiculation (blisters), scaling, and itching. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.[2]

Synthesis

Haloprogin synthesis: U.S. Patent 4,038,409 JP 42011734[3]

References

  1. ↑ "Haloprogin". Drugs@FDA. Food and Drug Administration. Retrieved 2007-02-17.
  2. ↑ "Haloprogin". DrugBank. University of Alberta. Nov 6, 2006. Retrieved 2007-02-17.
  3. ↑ Seki, S.; Nishihata, K.; Nakayama, T.; Ogawa, H. (1963). "Syntheses of Halophenyl-^|^gamma;-iodopropargyl Ethers which have High Antifungal Activity". Agricultural and Biological Chemistry 27 (2): 150. doi:10.1271/bbb1961.27.150.