HOXB8

Homeobox B8
Identifiers
SymbolsHOXB8 ; HOX2; HOX2D; Hox-2.4
External IDsOMIM: 142963 MGI: 96189 HomoloGene: 7768 GeneCards: HOXB8 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez321815416
EnsemblENSG00000120068ENSMUSG00000056648
UniProtP17481P09632
RefSeq (mRNA)NM_024016NM_010461
RefSeq (protein)NP_076921NP_034591
Location (UCSC)Chr 17:
46.69 – 46.69 Mb		Chr 11:
96.28 – 96.29 Mb
PubMed search

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.[3]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results is a reduction of compulsive grooming.[4]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXB8 homeobox B8".
  4. ↑ Shau-Kwaun Chen, Petr Tvrdik, Erik Peden, Scott Cho, Sen Wu1, Gerald Spangrude and Mario R. Capecchi (May 2010). "Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice". Cell 141 (5): 775–785. doi:10.1016/j.cell.2010.03.055. PMC 2894573. PMID 20510925.

Further reading

  • Peverali FA, D'Esposito M, Acampora D et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
  • Giampaolo A, Acampora D, Zappavigna V et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
  • Acampora D, D'Esposito M, Faiella A et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
  • Boncinelli E, Acampora D, Pannese M et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
  • Apiou F, Flagiello D, Cillo C et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
  • Vider BZ, Zimber A, Hirsch D et al. (1997). "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression". Biochem. Biophys. Res. Commun. 232 (3): 742–8. doi:10.1006/bbrc.1997.6364. PMID 9126347.
  • Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Fujino T, Yamazaki Y, Largaespada DA et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
  • Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation". Oncogene 20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID 11571641.
  • Greer JM, Capecchi MR (2002). "Hoxb8 is required for normal grooming behavior in mice". Neuron 33 (1): 23–34. doi:10.1016/S0896-6273(01)00564-5. PMID 11779477.
  • Kosaki K, Kosaki R, Suzuki T et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.