HOMER3
| Homer homolog 3 (Drosophila) | |||||||||||||
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 Rendering based on PDB 2P8V. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | HOMER3 ; HOMER-3; VESL3 | ||||||||||||
| External IDs | OMIM: 604800 MGI: 1347359 HomoloGene: 37972 GeneCards: HOMER3 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9454 | 26558 | |||||||||||
| Ensembl | ENSG00000051128 | ENSMUSG00000003573 | |||||||||||
| UniProt | Q9NSC5 | Q99JP6 | |||||||||||
| RefSeq (mRNA) | NM_001145721 | NM_001146153 | |||||||||||
| RefSeq (protein) | NP_001139193 | NP_001139625 | |||||||||||
| Location (UCSC) | Chr 19: 19.04 – 19.05 Mb | Chr 8: 70.28 – 70.29 Mb | |||||||||||
| PubMed search | |||||||||||||
Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.[1][2][3]
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.[3]
Interactions
HOMER3 has been shown to interact with TRPC1[4] and RYR1.[5]
See also
References
- ↑ Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Apr 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". J Mol Biol 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
- ↑ Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
- ↑ 3.0 3.1 "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)".
- ↑ Yuan, Joseph P; Kiselyov Kirill, Shin Dong Ming, Chen Jin, Shcheynikov Nikolay, Kang Shin H, Dehoff Marlin H, Schwarz Martin K, Seeburg Peter H, Muallem Shmuel, Worley Paul F (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell (United States) 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. ISSN 0092-8674. PMID 14505576.
- ↑ Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. (United States) 277 (47): 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.
Further reading
- Brakeman PR, Lanahan AA, O'Brien R et al. (1997). "Homer: a protein that selectively binds metabotropic glutamate receptors.". Nature 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.
- Xiao B, Tu JC, Petralia RS et al. (1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.". Neuron 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
- Feng W, Tu J, Yang T et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex.". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yuan JP, Kiselyov K, Shin DM et al. (2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.". Cell 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576.
- Ishiguro K, Xavier R (2004). "Homer-3 regulates activation of serum response element in T cells via its EVH1 domain.". Blood 103 (6): 2248–56. doi:10.1182/blood-2003-08-2671. PMID 14645007.
- Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.". BMC Genet. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Schreiner D, Müller K, Hofer HW (2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins.". FEBS Lett. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.